{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSNHG22 is an oncogenic long non‐coding RNA that has been found to be aberrantly upregulated in several human malignancies. In colorectal cancer, SNHG22 promotes cell proliferation, apoptosis resistance, migration, and invasion by sponging miR‑128‑3p and thereby enhancing E2F3 expression and activity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In hepatocellular carcinoma, elevated SNHG22 levels correlate with poor prognosis, where the RNA recruits EZH2 to bind DNMT1 at the miR‑16‑5p promoter, leading to DNA methylation‐mediated suppression of this tumor‐suppressive miRNA."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Similarly, in gastric cancer, SNHG22 not only enhances proliferation and invasion by binding to EZH2 to repress tumor suppressor genes and sponging miR‑200c‑3p to elevate Notch1 expression"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", but also, through its regulation of the miR‑101‑3p/E2F2 axis, further promotes malignant behaviors and tumor growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in cancer progression, SNHG22 has been implicated in other pathologic processes. In preeclampsia, for example, emerging evidence suggests that SNHG22 affects trophoblast function, indicating its broader impact on cellular regulation in non‐neoplastic diseases."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Moreover, in non‑small cell lung cancer, increased serum levels of SNHG22 have been associated with poor patient outcomes, underscoring its potential as a prognostic biomarker and reinforcing its role as a critical regulator of cellular proliferation and metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jianning Yao, Chunfeng Wang, Xuyang Dong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "lncRNA SNHG22 sponges miR‑128‑3p to promote the progression of colorectal cancer by upregulating E2F3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2021.5251"}], "href": "https://doi.org/10.3892/ijo.2021.5251"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34368861"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34368861"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yinxin Zhang, Changliang Lu, Haiwei Cui "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA SNHG22 facilitates hepatocellular carcinoma tumorigenesis and angiogenesis via DNA methylation of microRNA miR-16-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.1975969"}], "href": "https://doi.org/10.1080/21655979.2021.1975969"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34652260"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34652260"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xiaqiong Mao, Tao Ji, Aiguo Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ELK4-mediated lncRNA SNHG22 promotes gastric cancer progression through interacting with EZH2 and regulating miR-200c-3p/Notch1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-021-04228-z"}], "href": "https://doi.org/10.1038/s41419-021-04228-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34663788"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34663788"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Zhen Li, Zhiqiang Lang, Ting Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA SNHG22 promotes gastric cancer progression by regulating the miR-101-3p/e2f2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2022.2119515"}], "href": "https://doi.org/10.1080/15384101.2022.2119515"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36281526"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36281526"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xiaoying Wei, Yichong Yuan, Qiong Yang "}, {"type": "b", "children": [{"type": "t", "text": "SNHG22 promotes migration and invasion of trophoblasts via miR-128-3p/PCDH11X axis and activates PI3K/Akt signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clinics (Sao Paulo) (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.clinsp.2022.100055"}], "href": "https://doi.org/10.1016/j.clinsp.2022.100055"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35679761"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35679761"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Quan Cheng, Guoping Chen, Xiaojiao Wu, et al. 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