{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent evidence demonstrates that SNHG29, a long noncoding RNA also known as LRRC75A‐AS1, plays multifaceted roles in modulating tumor immunity and cell proliferation that appear to be highly context dependent. In colorectal cancer, one study reported that simvastatin suppresses SNHG29 expression to inhibit YAP activation and transcriptionally downregulate PD-L1, thereby promoting anti‐tumor immunity, whereas an independent study in the same cancer type observed that low endogenous levels of SNHG29 (LRRC75A‐AS1) are associated with enhanced tumor cell proliferation, invasion, and metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In hematological malignancies, SNHG29 exhibits further complexity: in FLT3‐ITD acute myeloid leukemia, it is abnormally downregulated and acts as a tumor suppressor by interacting with EP300 to modulate histone modifications and downstream oncogenic gene expression, while in chronic myeloid leukemia, its overexpression correlates with disease aggressiveness through its function as a competing endogenous RNA that sequesters miR‐483-3p, ultimately activating the PI3K/Akt pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn solid tumors such as triple‐negative breast cancer and cervical cancer, SNHG29 largely exhibits oncogenic properties. In triple‐negative breast cancer, SNHG29 acts as a sponge for miR‐380-3p, resulting in the upregulation of the oncogene BAALC and fostering cell proliferation, invasion, and the epithelial–mesenchymal transition. Similarly, in cervical cancer, SNHG29 delivered by M2 macrophage‐derived exosomes suppresses miR‐429, leading to increased SIX1 expression and activation of the STAT3/MMP-9 signaling axis, which in turn promotes tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its functions in oncogenesis, SNHG29 has also been investigated in a non‐cancer context. Its association with spontaneous preterm birth has been examined, suggesting that SNHG29 may serve as a potential biomarker for adverse pregnancy outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jianxiong Chen, Jiawen Lan, Zhiwei Ye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA LRRC75A-AS1 inhibits cell proliferation and migration in colorectal carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Biol Med (Maywood) (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1535370219874339"}], "href": "https://doi.org/10.1177/1535370219874339"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31505952"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31505952"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wen Ni, Hui Mo, Yuanyuan Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Targeting cholesterol biosynthesis promotes anti-tumor immunity by inhibiting long noncoding RNA SNHG29-mediated YAP activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Ther (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ymthe.2021.05.012"}], "href": "https://doi.org/10.1016/j.ymthe.2021.05.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33992804"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33992804"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Shan Liu, Jie Zhou, Xiangling Ye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel lncRNA SNHG29 regulates EP300- related histone acetylation modification and inhibits FLT3-ITD AML development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leukemia (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41375-023-01923-y"}], "href": "https://doi.org/10.1038/s41375-023-01923-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37157016"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37157016"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "XueFeng Feng, Lin Yang, Xiaojun Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA small nucleolar RNA host gene 29 drives chronic myeloid leukemia progression via microRNA-483-3p/Casitas B-lineage Lymphoma axis-mediated activation of the phosphoinositide 3-kinase/Akt pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Oncol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12032-023-02287-0"}], "href": "https://doi.org/10.1007/s12032-023-02287-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38252204"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38252204"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Sijie Li, Di Wu, Hongyao Jia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA LRRC75A-AS1 facilitates triple negative breast cancer cell proliferation and invasion via functioning as a ceRNA to modulate BAALC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-020-02821-2"}], "href": "https://doi.org/10.1038/s41419-020-02821-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32811810"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32811810"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Hong-Ying Sui, Xiu-Ying Cui, Cai-Xia Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LRRC75A-AS1 delivered by M2 macrophage exosomes promotes cervical cancer progression via enhancing SIX1 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.15780"}], "href": "https://doi.org/10.1111/cas.15780"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36892427"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36892427"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Jiayi Jiang, Haoyue Hu, Qian Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA SNHG29 regulates cell senescence via p53/p21 signaling in spontaneous preterm birth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Placenta (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.placenta.2020.10.009"}], "href": "https://doi.org/10.1016/j.placenta.2020.10.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33080448"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33080448"}]}]}]}