{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe collection of studies provided does not directly address SNORA11C. Instead, these abstracts focus on the diverse roles of methionine aminopeptidase‐2 (MetAP2) in regulating cellular processes such as angiogenesis, tumor cell proliferation, and tissue remodeling. Although SNORA11C—a small nucleolar RNA typically involved in RNA modification—is not mentioned in any of these reports, the work collectively underscores how precise modulation of protein processing by MetAP2 is critical for various biological outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFor instance, one study demonstrated that the interaction between S100A4 and MetAP2 may affect the intracellular distribution of MetAP2 (thus potentially influencing its substrate processing activity), which in turn plays a role in endothelial cell growth and tumor metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Additional investigations using conditional knockout models and RNA interference highlighted an essential role for MetAP2 in endothelial cell proliferation and even in orchestrating the circadian regulation of its own transcription, further establishing its impact on angiogenesis and cancer progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOther reports expanded on the spectrum of MetAP2’s activity by identifying specific protein substrates through advanced proteomic techniques and by demonstrating its involvement in fibrotic lung disease, skeletal muscle differentiation, lymphangiogenesis, and even cardioprotection against ischemia/reperfusion injury."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "9"}]}, {"type": "t", "text": " While these findings considerably advance our understanding of MetAP2’s multifaceted functions, they do not provide information regarding SNORA11C. Future work may explore whether SNORA11C, or other small nucleolar RNAs, intersect with the regulatory networks influenced by MetAP2, thereby linking RNA modification processes to the pathways governing cell proliferation and angiogenesis.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hideya Endo, Keizo Takenaga, Takayuki Kanno, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Methionine aminopeptidase 2 is a new target for the metastasis-associated protein, S100A4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M202244200"}], "href": "https://doi.org/10.1074/jbc.M202244200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11994292"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11994292"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jing-Ruey J Yeh, Rong Ju, Cathleen M Brdlik, et al. 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