{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSNORA24 is an H/ACA small nucleolar RNA that plays a critical role in guiding pseudouridine modifications on the 18S ribosomal RNA, thereby influencing the biophysical properties and fidelity of the ribosome. In the context of RAS-induced senescence, loss of SNORA24‐mediated modifications was shown to disrupt aminoacyl-transfer RNA selection and pre-translocation dynamics, resulting in increased translational miscoding and stop codon readthrough. This deficiency cooperates with oncogenic RAS to promote liver tumorigenesis, as evidenced by mouse models developing liver cancer closely resembling human steatohepatitic hepatocellular carcinoma, with low SNORA24 levels also correlating with increased lipid accumulation and poor patient survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn contrast, in colorectal cancer, SNORA24 is found to be upregulated and operates through an oncogenic pathway. Elevated SNORA24 expression in colorectal tumors is significantly associated with clinical features such as age and a history of colon polyps, and it promotes cell cycle progression (facilitating the G1/S phase transition), cell proliferation, colony formation, and xenograft tumor growth. Mechanistically, SNORA24 contributes to tumorigenesis by stabilizing the p53 protein via a proteasomal degradation pathway, while its knockdown triggers extensive apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Mary McMahon, Adrian Contreras, Mikael Holm, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A single H/ACA small nucleolar RNA mediates tumor suppression downstream of oncogenic RAS."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.48847"}], "href": "https://doi.org/10.7554/eLife.48847"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31478838"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31478838"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Liping Shen, Chuxian Lin, Wenqing Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Involvement of the oncogenic small nucleolar RNA SNORA24 in regulation of p53 stability in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biol Toxicol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10565-022-09765-7"}], "href": "https://doi.org/10.1007/s10565-022-09765-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36087186"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36087186"}]}]}]}