{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough none of the provided abstracts mention SNORA25 or describe its function, the collective literature instead offers extensive insights into the multifaceted roles of miR‐30a (in its various isoforms) in regulating autophagy, cell survival, inflammation, and differentiation in diverse biological contexts. For example, several studies demonstrate that miR‐30a modulates autophagy by directly targeting key effectors such as beclin 1 in cancer and cardiac cells, thereby influencing chemoresistance and hypertrophy."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOther reports highlight that miR‐30a—whether acting alone or as part of competitive endogenous RNA networks—also plays pivotal roles in suppressing or exacerbating cellular injury. In ischemia/reperfusion models, neurodegeneration, and inflammatory conditions, altered levels of miR‐30a (including the −5p and −3p forms) regulate apoptosis, oxidative stress, and key signalling pathways by targeting molecules such as Neurod1, HSPA5, CLCF1, and Notch1."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition, miR‐30a is implicated in the regulation of differentiation processes and tissue remodelling. Its involvement spans from controlling osteogenic differentiation and adipocyte function to modulating the fate of spermatogonial stem cells and even influencing immunoregulatory T‐cell subsets, as well as contributing to pathological angiogenesis in retinal and pulmonary tissues."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "16"}]}, {"type": "t", "text": " \n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn summary, while the function of SNORA25 remains unexplored in these abstracts, the reported studies collectively reveal that miR‐30a family members are central modulators of autophagy, apoptosis, inflammation, and differentiation in numerous pathophysiological processes. This contrast underscores the need for further research to determine whether small nucleolar RNAs such as SNORA25 may similarly contribute to the regulation of these complex cellular networks."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "17", "end_ref": "21"}]}, {"type": "t", "text": " \n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiaomin Zhong, Ning Li, Shun Liang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of microRNAs regulating reprogramming factor LIN28 in embryonic stem cells and cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.169607"}], "href": "https://doi.org/10.1074/jbc.M110.169607"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20947512"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20947512"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zhenyou Zou, Linping Wu, Hanying Ding, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-30a sensitizes tumor cells to cis-platinum via suppressing beclin 1-mediated autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.307405"}], "href": "https://doi.org/10.1074/jbc.M111.307405"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22157765"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22157765"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Peng Wang, Nan Zhang, Jia Liang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Micro-RNA-30a regulates ischemia-induced cell death by targeting heat shock protein HSPA5 in primary cultured cortical neurons and mouse brain after stroke."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jnr.23637"}], "href": "https://doi.org/10.1002/jnr.23637"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26301516"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26301516"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xuesong Yin, Chenghai Peng, Wenhu Ning, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-30a downregulation aggravates pressure overload-induced cardiomyocyte hypertrophy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-012-1552-z"}], "href": "https://doi.org/10.1007/s11010-012-1552-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23660952"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23660952"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jing-Jing Wang, Zi-Dong Bie, Chao-Feng Sun "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA AK088388 regulates autophagy through miR-30a to affect cardiomyocyte injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.28300"}], "href": "https://doi.org/10.1002/jcb.28300"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30635942"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30635942"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Ye Fang, Lin Zou, Wei He "}, {"type": "b", "children": [{"type": "t", "text": "miR‑30a‑5p mitigates autophagy by regulating the Beclin‑1/ATG16 pathway in renal ischemia/reperfusion injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijmm.2021.4977"}], "href": "https://doi.org/10.3892/ijmm.2021.4977"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34080645"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34080645"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Wei Wei, Yang Yang, Jian Cai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-30a-5p Suppresses Tumor Metastasis of Human Colorectal Cancer by Targeting ITGB3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000447823"}], "href": "https://doi.org/10.1159/000447823"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27576787"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27576787"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Xiaodong Fu, Yi Shen, Weili Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-30a-5p ameliorates spinal cord injury-induced inflammatory responses and oxidative stress by targeting Neurod 1 through MAPK/ERK signalling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Exp Pharmacol Physiol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/1440-1681.12856"}], "href": "https://doi.org/10.1111/1440-1681.12856"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28925510"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28925510"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Ting Sun, Kaiyue Zhao, Mimin Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-30a-5p induces Aβ production via inhibiting the nonamyloidogenic pathway in Alzheimer's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pharmacol Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.phrs.2022.106153"}], "href": "https://doi.org/10.1016/j.phrs.2022.106153"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35257899"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35257899"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "He-Da Zhang, Lin-Hong Jiang, Da-Wei Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-30a inhibits the biological function of breast cancer cells by targeting Notch1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Med (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijmm.2017.3084"}], "href": "https://doi.org/10.3892/ijmm.2017.3084"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28765900"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28765900"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Qi Wang, Jia-Fei Xie, Ting-Ting Yao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA‑30a‑5p regulates cypermethrin-induced apoptosis of Sertoli cells by targeting KLF9 in vitro."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reprod Toxicol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.reprotox.2023.108414"}], "href": "https://doi.org/10.1016/j.reprotox.2023.108414"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37245696"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37245696"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Pradip K Saha, Mark P Hamilton, Kimal Rajapakshe, et al. "}, {"type": "b", "children": [{"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "miR-30a"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " targets gene networks that promote browning of human and mouse adipocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Endocrinol Metab (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpendo.00045.2020"}], "href": "https://doi.org/10.1152/ajpendo.00045.2020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32799658"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32799658"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Ruyi Zhang, Yaguang Weng, Baolin Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BMP9-induced osteogenic differentiation is partially inhibited by miR-30a in the mesenchymal stem cell line C3H10T1/2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Histol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10735-015-9628-1"}], "href": "https://doi.org/10.1007/s10735-015-9628-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26205653"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26205653"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Maryam Khanehzad, Seyed Mehdi Nourashrafeddin, Farid Abolhassani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-30a-5p promotes differentiation in neonatal mouse spermatogonial stem cells (SSCs)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reprod Biol Endocrinol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12958-021-00758-5"}], "href": "https://doi.org/10.1186/s12958-021-00758-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34108007"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34108007"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Xia Li, Ruisheng Xu, Jun-Xing Ye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Suppression of bone remodeling associated with long-term bisphosphonate treatment is mediated by microRNA-30a-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2022.2060584"}], "href": "https://doi.org/10.1080/21655979.2022.2060584"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35412438"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35412438"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Sandra L Grimm, Samuel Reddick, Xiaoyu Dong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of microRNA-30a and sex-specific effects on the neonatal hyperoxic lung injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Sex Differ (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13293-023-00535-6"}], "href": "https://doi.org/10.1186/s13293-023-00535-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37553579"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37553579"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Dong Guo, Ji Ma, Lei Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Down-Regulation of Lncrna MALAT1 Attenuates Neuronal Cell Death Through Suppressing Beclin1-Dependent Autophagy by Regulating Mir-30a in Cerebral Ischemic Stroke."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000480337"}], "href": "https://doi.org/10.1159/000480337"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28854438"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28854438"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Jianliang Chen, Yue Yu, Shu Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-30a ameliorates hepatic fibrosis by inhibiting Beclin1-mediated autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.13278"}], "href": "https://doi.org/10.1111/jcmm.13278"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28766848"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28766848"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Mengying Hu, Ying Wang, Zhengsheng Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hepatic macrophages act as a central hub for relaxin-mediated alleviation of liver fibrosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Nanotechnol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41565-020-00836-6"}], "href": "https://doi.org/10.1038/s41565-020-00836-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33495618"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33495618"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Bin Bin Li, Yun Long Chen, Fuzhen Pang "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-30a Targets ATG5 and Attenuates Airway Fibrosis in Asthma by Suppressing Autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Inflammation (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10753-019-01076-0"}], "href": "https://doi.org/10.1007/s10753-019-01076-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31748850"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31748850"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Wenliang Wu, Jiali Gao, Dian Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epithelial microRNA-30a-3p targets RUNX2/HMGB1 axis to suppress airway eosinophilic inflammation in asthma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Respir Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12931-022-01933-x"}], "href": "https://doi.org/10.1186/s12931-022-01933-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35093061"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35093061"}]}]}]}