SNORA33 Gene

HGNC Family Non-coding RNAs
Name small nucleolar RNA, H/ACA box 33
Description Predicted to be involved in RNA processing. Predicted to be located in nucleolus. [provided by Alliance of Genome Resources, Mar 2025]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSNORA33 is an H/ACA–box small nucleolar RNA that guides the site‐specific pseudouridylation of ribosomal RNA, targeting residue 28S–Ψ966. In a study employing CRISPR/Cas9 knockout in human SW1353 cells, depletion of SNORA33 (but not SNORA22) was shown to significantly reduce pseudouridylation at this position, underscoring its unique role in rRNA modification. This modification is an integral part of generating ribosome heterogeneity by influencing ribosomal protein composition and, consequently, the translational capacity and fidelity of the ribosome."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThe loss of SNORA33‐directed pseudouridylation at 28S–Ψ966 leads to alterations in ribosome structure and function, which in turn precipitates specific changes in the cellular proteome. These findings demonstrate that dynamic adjustments in rRNA modification, mediated by SNORA33, allow cells to fine‐tune protein synthesis in response to disease‐relevant environmental challenges, potentially opening new avenues for therapeutic intervention in conditions where ribosome function is compromised."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Alzbeta Chabronova, Guus van den Akker, Bas A C Housmans, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Depletion of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "SNORA33"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Abolishes ψ of 28S-U4966 and Affects the Ribosome Translational Apparatus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms241612578"}], "href": "https://doi.org/10.3390/ijms241612578"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37628759"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37628759"}]}]}]}
Synonyms ACA33
NCBI Gene ID 594839
API
Download Associations
Predicted Functions View SNORA33's ARCHS4 Predicted Functions.
Co-expressed Genes View SNORA33's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View SNORA33's ARCHS4 Predicted Functions.

Functional Associations

SNORA33 has 1,506 functional associations with biological entities spanning 4 categories (molecular profile, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 19 datasets.

Click the + buttons to view associations for SNORA33 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of SNORA33 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
CellMarker Gene-Cell Type Associations cell types associated with SNORA33 gene from the CellMarker Gene-Cell Type Associations dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of SNORA33 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of SNORA33 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at SNORA33 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of SNORA33 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of SNORA33 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of SNORA33 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of SNORA33 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations transcription factor perturbations changing expression of SNORA33 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of SNORA33 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of SNORA33 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
GTEx Tissue-Specific Aging Signatures tissue samples with high or low expression of SNORA33 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of SNORA33 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of SNORA33 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles cell lines with high or low expression of SNORA33 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of SNORA33 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of SNORA33 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at SNORA33 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.