{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe collection of abstracts provided does not include any direct mention or investigation of SNORA38. In fact, none of the studies address the function or molecular interactions of this small nucleolar RNA. Typically, SNORA38—as a member of the H/ACA box small nucleolar RNAs—is known from other work to guide pseudouridylation of ribosomal RNA (rRNA) and thereby contribute to rRNA maturation and ribosome biogenesis; however, its role is not explored or referenced in these abstracts."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nInstead, several studies focus on the regulation of cell motility and cytoskeletal dynamics—with molecules such as Rac1, Nap1, and the SCAR/WAVE complex—in processes like lamellipodia formation, embryonic morphogenesis, myoblast fusion, and differentiation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "3"}, {"type": "fg_f", "ref": "2"}, {"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " These studies highlight the importance of actin polymerization in cellular functions and, by extension, underscore the complexity of post‐transcriptional regulation in cellular systems—an area where small nucleolar RNAs like SNORA38 would typically be considered, even though they are not discussed in these works.\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOther abstracts detail the roles of the relaxin-3 neuropeptide and its receptor RXFP3 in modulating neural circuits that regulate arousal, stress responses, feeding, circadian activity, cognitive performance, and sodium appetite."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "17"}]}, {"type": "t", "text": " Although these studies provide extensive insight into neuropeptide-mediated signal transduction and behavior, they too do not investigate or mention SNORA38.\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn summary, while the abstracts collectively shed light on critical aspects of cytoskeletal regulation and neuromodulatory signaling, they do not offer any experimental data or insights concerning the function of SNORA38. Therefore, to understand the role of SNORA38, one would need to consult literature that specifically investigates small nucleolar RNA-mediated rRNA modification and ribosome biogenesis.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Anika Steffen, Klemens Rottner, Julia Ehinger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.emboj.7600084"}], "href": "https://doi.org/10.1038/sj.emboj.7600084"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14765121"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14765121"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Nader Omidvar, Lorna Pearn, Alan K Burnett, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ral is both necessary and sufficient for the inhibition of myeloid differentiation mediated by Ras."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.26.10.3966-3975.2006"}], "href": "https://doi.org/10.1128/MCB.26.10.3966-3975.2006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16648489"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16648489"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Andrew S Rakeman, Kathryn V Anderson "}, {"type": "b", "children": [{"type": "t", "text": "Axis specification and morphogenesis in the mouse embryo require Nap1, a regulator of WAVE-mediated actin branching."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.02473"}], "href": "https://doi.org/10.1242/dev.02473"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16831833"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16831833"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Scott J Nowak, Patrick C Nahirney, Anna-Katerina Hadjantonakis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nap1-mediated actin remodeling is essential for mammalian myoblast fusion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.047597"}], "href": "https://doi.org/10.1242/jcs.047597"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19706686"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19706686"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Karthic Swaminathan, Andrew Campbell, Vassilis Papalazarou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The RAC1 Target NCKAP1 Plays a Crucial Role in the Progression of Braf;Pten-Driven Melanoma in Mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Invest Dermatol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jid.2020.06.029"}], "href": "https://doi.org/10.1016/j.jid.2020.06.029"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32777214"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32777214"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Masaki Tanaka, Yoshihisa Watanabe, Kanji Yoshimoto "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of relaxin 3 gene expression via cAMP-PKA in a neuroblastoma cell line."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jnr.21895"}], "href": "https://doi.org/10.1002/jnr.21895"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18831067"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18831067"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Craig M Smith, Pei-Juan Shen, Avantika Banerjee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distribution of relaxin-3 and RXFP3 within arousal, stress, affective, and cognitive circuits of mouse brain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Comp Neurol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cne.22442"}], "href": "https://doi.org/10.1002/cne.22442"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20737598"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20737598"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "C M Smith, I T Hosken, S W Sutton, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Relaxin-3 null mutation mice display a circadian hypoactivity phenotype."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Brain Behav (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1601-183X.2011.00730.x"}], "href": "https://doi.org/10.1111/j.1601-183X.2011.00730.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21899720"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21899720"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Craig M Smith, Andrew J Lawrence, Steve W Sutton, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Behavioral phenotyping of mixed background (129S5:B6) relaxin-3 knockout mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann N Y Acad Sci (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1749-6632.2009.03953.x"}], "href": "https://doi.org/10.1111/j.1749-6632.2009.03953.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19416195"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19416195"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Craig M Smith, Lesley L Walker, Berenice E Chua, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Involvement of central relaxin-3 signalling in sodium (salt) appetite."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Physiol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1113/EP085349"}], "href": "https://doi.org/10.1113/EP085349"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26147879"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26147879"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "M Haidar, G Guèvremont, C Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Relaxin-3 inputs target hippocampal interneurons and deletion of hilar relaxin-3 receptors in \"floxed-RXFP3\" mice impairs spatial memory."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hippocampus (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hipo.22709"}], "href": "https://doi.org/10.1002/hipo.22709"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28100033"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28100033"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Nailyam Nasirova, Lely A Quina, Glenn Morton, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mapping Cell Types and Efferent Pathways in the Ascending Relaxin-3 System of the Nucleus Incertus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "eNeuro (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/ENEURO.0272-20.2020"}], "href": "https://doi.org/10.1523/ENEURO.0272-20.2020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33055197"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33055197"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Ihaia T Hosken, Craig M Smith, Berenice E Chua, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Consequences of relaxin-3 null mutation in mice on food-entrainable arousal."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ital J Anat Embryol (2013)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24640569"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24640569"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Craig M Smith, Anna Blasiak, Despina E Ganella, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Viral-mediated delivery of an RXFP3 agonist into brain promotes arousal in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ital J Anat Embryol (2013)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24640570"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24640570"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Craig M Smith, Berenice E Chua, Andrew W Walker, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Potential hypothalamic targets of relaxin-3 innervation: a perspective."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ital J Anat Embryol (2013)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24640571"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24640571"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Craig M Smith, Ihaia T Hosken, Natalie L Downer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pharmacological activation of RXFP3 is not orexigenic in C57BL/6J mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ital J Anat Embryol (2013)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24640572"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24640572"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Masaki Tanaka, Eriko Furube, Miku Aoki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Behavioral analysis of relaxin-3 deficient mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ital J Anat Embryol (2013)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24640573"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24640573"}]}]}]}