{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough the provided abstracts do not discuss SNORA41 directly, they offer extensive insights into ubiquitin‐related pathways that govern critical cellular processes such as protein quality control, stress responses, mitochondrial maintenance, and cell proliferation. For example, one study shows that PINK1‐dependent phosphorylation re‐activates Parkin’s E3 ubiquitin ligase activity through a transthiolation reaction essential for labeling damaged mitochondria for degradation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similarly, several studies describe how stress‐inducible polyubiquitin genes (UbC/Ubc) are required for maintaining adequate ubiquitin levels during episodes of cellular stress, ensuring proper degradation of misfolded proteins and influencing cell survival and development."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOther reports in the collection highlight the role of ubiquitin in modulating key signaling pathways and chromatin dynamics. In one study, the ubiquitin status of smoothened (Smo) is shown to regulate its ciliary localization and activity within the Hedgehog signaling pathway"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", while another demonstrates that changes in ubiquitin conjugation correlate with altered levels of monoubiquitylated histone H2A in a neurodegenerative disease model."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Additionally, regulation of ubiquitin C expression by nuclear receptors, as well as its suitability as a reference gene in quantitative PCR studies, emphasizes the broad regulatory roles the ubiquitin system plays across diverse biological contexts."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSNORA41, a small nucleolar RNA typically involved in guiding rRNA modifications during ribosome biogenesis, represents a distinct class of regulatory molecules compared to the protein-centric ubiquitin pathways illustrated in these abstracts. Although none of the studies provide experimental evidence linking SNORA41 to the pathways discussed, one can speculate that non‐coding RNAs like SNORA41 might intersect with ubiquitin-mediated processes, perhaps by modulating gene expression or ribosome function under stress. However, in the absence of direct data from these abstracts, the specific functional contribution of SNORA41 remains to be elucidated.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Masahiro Iguchi, Yuki Kujuro, Kei Okatsu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Parkin-catalyzed ubiquitin-ester transfer is triggered by PINK1-dependent phosphorylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M113.467530"}], "href": "https://doi.org/10.1074/jbc.M113.467530"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23754282"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23754282"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kwon-Yul Ryu, René Maehr, Catherine A Gilchrist, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The mouse polyubiquitin gene UbC is essential for fetal liver development, cell-cycle progression and stress tolerance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.emboj.7601722"}], "href": "https://doi.org/10.1038/sj.emboj.7601722"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17491588"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17491588"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Mi-Nam Kim, Juhee Choi, Han-Wook Ryu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Disruption of polyubiquitin gene Ubc leads to attenuated resistance against arsenite-induced toxicity in mouse embryonic fibroblasts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamcr.2015.02.010"}], "href": "https://doi.org/10.1016/j.bbamcr.2015.02.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25701757"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25701757"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Kwon-Yul Ryu, Hyejin Park, Derrick J Rossi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Perturbation of the hematopoietic system during embryonic liver development due to disruption of polyubiquitin gene Ubc in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0032956"}], "href": "https://doi.org/10.1371/journal.pone.0032956"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22393459"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22393459"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Hyejin Park, Min-Sik Yoon, Kwon-Yul Ryu "}, {"type": "b", "children": [{"type": "t", "text": "Disruption of polyubiquitin gene Ubc leads to defective proliferation of hepatocytes and bipotent fetal liver epithelial progenitor cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2013.05.003"}], "href": "https://doi.org/10.1016/j.bbrc.2013.05.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23669039"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23669039"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Paurav B Desai, Michael W Stuck, Bo Lv, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ubiquitin links smoothened to intraflagellar transport to regulate Hedgehog signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201912104"}], "href": "https://doi.org/10.1083/jcb.201912104"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32435793"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32435793"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "John S Bett, Caroline L Benn, Kwon-Yul Ryu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The polyubiquitin Ubc gene modulates histone H2A monoubiquitylation in the R6/2 mouse model of Huntington's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1582-4934.2008.00543.x"}], "href": "https://doi.org/10.1111/j.1582-4934.2008.00543.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19602042"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19602042"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Dae J Kim, Taro E Akiyama, Fred S Harman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Peroxisome proliferator-activated receptor beta (delta)-dependent regulation of ubiquitin C expression contributes to attenuation of skin carcinogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M312063200"}], "href": "https://doi.org/10.1074/jbc.M312063200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15033975"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15033975"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Tina C Albershardt, Brian M Iritani, Alanna Ruddell "}, {"type": "b", "children": [{"type": "t", "text": "Evaluation of reference genes for quantitative PCR analysis of mouse lymphocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol Methods (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jim.2012.07.020"}], "href": "https://doi.org/10.1016/j.jim.2012.07.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22884776"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22884776"}]}]}]}