| HGNC Family | Non-coding RNAs |
| Name | small nucleolar RNA, H/ACA box 53 |
| Description | Predicted to be involved in RNA processing. Predicted to be located in nucleolus. [provided by Alliance of Genome Resources, Mar 2025] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough SNORA53 is generally recognized as a small nucleolar RNA involved in the modification and processing of ribosomal RNAs, the provided abstract (1) does not discuss or attribute any specific function to SNORA53. Instead, the study detailed in that abstract focuses on keratinocyte biology—specifically, on how keratinocytes internalize melanosomes from melanocytes and retain them in the perinuclear region, where a group of Rab family small GTPases is enriched. The work identifies several Rab proteins associated with these melanosome‐containing compartments and, in particular, highlights Rab7B/42 as a key facilitator of protein degradation on incorporated melanosomes, a process that likely contributes to protecting nuclear DNA against ultraviolet injury."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Soujiro Marubashi, Mitsunori Fukuda "}, {"type": "b", "children": [{"type": "t", "text": "Rab7B/42 Is Functionally Involved in Protein Degradation on Melanosomes in Keratinocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Struct Funct (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1247/csf.19039"}], "href": "https://doi.org/10.1247/csf.19039"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32037382"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32037382"}]}]}]}
|
| Synonyms | ACA53 |
| NCBI Gene ID | 677832 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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SNORA53 has 1,007 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 13 datasets.
Click the + buttons to view associations for SNORA53 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of SNORA53 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of SNORA53 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at SNORA53 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of SNORA53 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of SNORA53 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of SNORA53 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of SNORA53 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of SNORA53 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of SNORA53 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of SNORA53 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of SNORA53 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at SNORA53 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of SNORA53 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |