SNORA56 Gene

HGNC Family Non-coding RNAs
Name small nucleolar RNA, H/ACA box 56
Description Biosynthesis of stable cellular RNAs such as tRNAs, rRNAs, snRNAs, and snoRNAs is aided by covalent nucleotide modification after transcription. The modified nucleotides are involved in correct RNA folding, establishment of correct RNA-RNA and RNA-protein interactions, and in the correct function of mature RNAs. The RNA encoded by this gene is thought to mediate the pseudouridylation of residue U1664 of 28S rRNA. [provided by RefSeq, Feb 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSNORA56, a small nucleolar RNA, has emerged as a potential regulatory molecule in colorectal cancer (CRC) by influencing key metabolic processes and cell death pathways. In CRC, reprogrammed metabolism is a hallmark of tumorigenesis, and recent therapeutic strategies have focused on ferroptosis—an iron-dependent form of programmed cell death—as a novel treatment approach. Although the precise mechanisms remain to be fully elucidated, SNORA56 may modulate cellular susceptibility to ferroptosis by affecting metabolic reprogramming and the oxidative stress response, thereby contributing to carcinogenesis and impacting tumor progression. Further investigation into SNORA56’s role could reveal new insights into its function as a mediator of ferroptosis and a prospective target for CRC therapy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chang Xu, Zhixuan Bian, Xinyue Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SNORA56-mediated pseudouridylation of 28 S rRNA inhibits ferroptosis and promotes colorectal cancer proliferation by enhancing GCLC translation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-023-02906-8"}], "href": "https://doi.org/10.1186/s13046-023-02906-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38049865"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38049865"}]}]}]}
Synonyms ACA56
NCBI Gene ID 677835
API
Download Associations
Predicted Functions View SNORA56's ARCHS4 Predicted Functions.
Co-expressed Genes View SNORA56's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View SNORA56's ARCHS4 Predicted Functions.

Functional Associations

SNORA56 has 1,285 functional associations with biological entities spanning 4 categories (molecular profile, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 19 datasets.

Click the + buttons to view associations for SNORA56 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of SNORA56 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of SNORA56 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of SNORA56 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of SNORA56 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at SNORA56 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of SNORA56 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of SNORA56 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of SNORA56 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of SNORA56 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of SNORA56 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of SNORA56 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
HPA Tissue Protein Expression Profiles tissues with high or low expression of SNORA56 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of SNORA56 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of SNORA56 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles cell lines with high or low expression of SNORA56 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of SNORA56 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of SNORA56 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at SNORA56 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
TCGA Signatures of Differentially Expressed Genes for Tumors tissue samples with high or low expression of SNORA56 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.