{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe provided abstracts primarily focus on the regulatory roles of the NatB complex and its mediated N-terminal acetylation in cellular processes. In one study, the authors demonstrated that NatB‐mediated N-terminal acetylation of the pro-apoptotic protein Bax is critical for maintaining its inactive conformation in the cytosol, thereby controlling its mitochondrial targeting and preventing inadvertent cytochrome c release."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn a parallel study, the NatB complex components, Nat5 and Mdm20, are shown to have key roles in the proliferation and differentiation of neural progenitors during embryonic brain development. Differential expression patterns of these proteins suggest that while they often function as a complex, Mdm20 may also have NatB-independent roles in certain neuronal subtypes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nNotably, neither of these abstracts provides any information regarding the function of SNORA57. Although SNORA57 is a small nucleolar RNA typically implicated in RNA modification processes, its role cannot be inferred from the described studies on protein acetylation and neural development. Future research will be necessary to explore any potential connection between SNORA57 and the NatB-mediated regulatory networks discussed in these works.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sara Alves, Leire Neiri, Susana Rodrigues Chaves, et al. "}, {"type": "b", "children": [{"type": "t", "text": "N-terminal acetylation modulates Bax targeting to mitochondria."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biochem Cell Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biocel.2017.12.004"}], "href": "https://doi.org/10.1016/j.biocel.2017.12.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29233735"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29233735"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kyoji Ohyama, Kunihiko Yasuda, Kazuko Onga, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Spatio-temporal expression pattern of the NatB complex, Nat5/Mdm20 in the developing mouse brain: implications for co-operative versus non-co-operative actions of Mdm20 and Nat5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene Expr Patterns (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gep.2011.11.001"}], "href": "https://doi.org/10.1016/j.gep.2011.11.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22101279"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22101279"}]}]}]}