{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough none of the provided abstracts explicitly address SNORA5A, its established role as a small nucleolar RNA involved in guiding pseudouridylation during rRNA maturation suggests it is a critical contributor to ribosome biogenesis. In this context, SNORA5A may ensure proper rRNA modification and ribosome assembly, which is fundamental for maintaining the fidelity of protein synthesis and for mounting effective p53‐mediated stress responses. These studies emphasize that when ribosome biogenesis is perturbed, the downstream activation of tumor suppressor pathways, such as those involving p53 and its homolog TAp73, can regulate cell cycle arrest and apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\nDisruption in ribosomal integrity—through misregulation of ribosomal proteins like RPL5 and RPL11—impairs the delicate balance between ribosome production and p53 activation. Because snoRNAs such as SNORA5A are integral to the modification and maturation of rRNAs, any functional aberration in SNORA5A could mimic or exacerbate ribosomal stress conditions, thereby indirectly potentiating the RP–MDM2–p53 signaling cascade that controls cell proliferation, DNA damage responses, and apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n\nFurthermore, in vivo models of ribosomal protein haploinsufficiency illustrate that defects in ribosome biogenesis can lead to significant pathophysiological outcomes such as impaired hematopoiesis, macrocytic anemia, and altered differentiation of erythroid precursors. By ensuring proper rRNA modification and ribosome assembly, SNORA5A may be viewed as an upstream contributor to sustaining the ribosomal function that is necessary to avoid such stress-induced cellular failures. These findings underscore the potential for noncoding RNAs, including SNORA5A, to influence processes central to both normal development and disease, as demonstrated in multiple experimental systems."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lucia Morgado-Palacin, Susana Llanos, Manuel Serrano "}, {"type": "b", "children": [{"type": "t", "text": "Ribosomal stress induces L11- and p53-dependent apoptosis in mouse pluripotent stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/cc.11.3.19002"}], "href": "https://doi.org/10.4161/cc.11.3.19002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22262176"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22262176"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "X Zhou, Q Hao, Q Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ribosomal proteins L11 and L5 activate TAp73 by overcoming MDM2 inhibition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Differ (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cdd.2014.167"}], "href": "https://doi.org/10.1038/cdd.2014.167"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25301064"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25301064"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Takuya Kamio, Bai-wei Gu, Timothy S Olson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mice with a Mutation in the Mdm2 Gene That Interferes with MDM2/Ribosomal Protein Binding Develop a Defect in Erythropoiesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0152263"}], "href": "https://doi.org/10.1371/journal.pone.0152263"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27042854"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27042854"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Raymond T Doty, Xiaowei Yan, Changting Meng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Single-cell analysis of erythropoiesis in Rpl11 haploinsufficient mice reveals insight into the pathogenesis of Diamond-Blackfan anemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Hematol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.exphem.2021.02.010"}], "href": "https://doi.org/10.1016/j.exphem.2021.02.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33631277"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33631277"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Derek A Franklin, Shijie Liu, Aiwen Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ribosomal protein RPL11 haploinsufficiency causes anemia in mice via activation of the RP-MDM2-p53 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jbc.2022.102739"}], "href": "https://doi.org/10.1016/j.jbc.2022.102739"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36435197"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36435197"}]}]}]}