{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTumor-educated platelets (TEPs) have emerged as a promising noninvasive source for cancer biomarkers, and recent research has highlighted the upregulation of small nucleolar RNAs (snoRNAs) in these platelets from patients with esophageal cancer (ESCA). In particular, SNORA68, along with SNORA58 and SNORD93, was found to be significantly elevated in both early-stage and advanced ESCA patients compared with healthy controls. This study utilized RNA extraction from TEPs followed by RT‑qPCR analysis and receiver operating characteristic (ROC) evaluation, revealing that SNORA68 possesses a robust diagnostic potential with an excellent area under the curve, supporting its role as a circulating biomarker for ESCA diagnosis and early detection."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThe methodological approach involved isolating platelet precipitates from platelet‑rich plasma using low‑speed centrifugation, with subsequent RNA extraction via Trizol™ reagent. The expression profile of SNORA68 was then quantitatively assessed, confirming that its elevated levels in TEPs can distinguish ESCA patients from healthy individuals effectively. Such differential expression underscores the importance of SNORA68 in the early detection of esophageal cancer, as its sensitivity and specificity are demonstrated through strong diagnostic performance metrics."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nCollectively, these findings underscore the growing significance of snoRNAs in cancer diagnostics. SNORA68, in particular, shows potential not only as a diagnostic biomarker but also as an integral component of noninvasive blood‐based screening strategies for esophageal cancer. Future studies with larger patient cohorts are warranted to further validate SNORA68’s clinical utility and to potentially integrate it into early detection protocols for improved patient outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Qianru Zhang, Zhao Bi, Xingguo Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor-educated platelet "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "SNORA58"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": ", "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "SNORA68"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " and "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "SNORD93"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " as novel diagnostic biomarkers for esophageal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Future Oncol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2217/fon-2023-0129"}], "href": "https://doi.org/10.2217/fon-2023-0129"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37129021"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37129021"}]}]}]}