{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe collection of studies provided delves into a number of critical metabolic and cellular processes, including transporter‐mediated ion and nutrient absorption and the fine-tuning of proton/amino acid co‐transport. For instance, enhanced intestinal NaCl, water, and fructose transport mediated by proteins such as Slc26a6 and Slc2a5 (as detailed in study 18496516) together with the rigorous kinetic characterization of the proton/amino acid transporter PAT1 (15504109) underscore key mechanisms by which dietary inputs impact systemic metabolic regulation. Notably, however, none of these reports address or implicate SNORA72 in these processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOther studies in this set investigate mitochondrial health and cytoprotection. Investigations into mitochondrial proteins—particularly the LEA protein PRELI—reveal its essential role in sustaining mitochondrial membrane potential, bolstering respiratory chain function, and protecting cells from apoptosis (14640972, 21364629, 22666421). Such findings provide important insights into mechanisms of cellular defense and bioenergetic regulation, yet they do not implicate SNORA72 in these mitochondrial processes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurther, the interplay between amino acid transport and metabolic signaling is highlighted by studies on nutrient absorption and mTORC1 activation. Research focusing on the peptide transporter PEPT1 in high‐fat diet contexts (24425764) and on lysosomal amino acid sensing via SLC38A9 and SLC36A1 (34572527) expands our understanding of cellular adaptations in nutrient homeostasis. Despite the depth of these insights, none of the studies presented examines or assigns a role to SNORA72, leaving its function unaddressed within this body of work."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Anurag Kumar Singh, Hassane Amlal, Patrick J Haas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Fructose-induced hypertension: essential role of chloride and fructose absorbing transporters PAT1 and Glut5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Kidney Int (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ki.2008.184"}], "href": "https://doi.org/10.1038/ki.2008.184"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18496516"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18496516"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Martin Foltz, Manuela Mertl, Veronika Dietz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Kinetics of bidirectional H+ and substrate transport by the proton-dependent amino acid symporter PAT1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20041519"}], "href": "https://doi.org/10.1042/BJ20041519"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15504109"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15504109"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Elizabeth J Fox, Sally A Stubbs, Jimmy Kyaw Tun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PRELI (protein of relevant evolutionary and lymphoid interest) is located within an evolutionarily conserved gene cluster on chromosome 5q34-q35 and encodes a novel mitochondrial protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20031504"}], "href": "https://doi.org/10.1042/BJ20031504"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14640972"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14640972"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "M R McKeller, S Herrera-Rodriguez, W Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vital function of PRELI and essential requirement of its LEA motif."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cddis.2009.19"}], "href": "https://doi.org/10.1038/cddis.2009.19"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21364629"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21364629"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Wenbin Ma, Morgan R McKeller, Roberto Rangel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Spare PRELI gene loci: failsafe chromosome insurance?"}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0037949"}], "href": "https://doi.org/10.1371/journal.pone.0037949"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22666421"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22666421"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Thi Thu Huong Do, Patrick Hindlet, Anne-Judith Waligora-Dupriet, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Disturbed intestinal nitrogen homeostasis in a mouse model of high-fat diet-induced obesity and glucose intolerance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Endocrinol Metab (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpendo.00437.2013"}], "href": "https://doi.org/10.1152/ajpendo.00437.2013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24425764"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24425764"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Dan Wang, Xuebin Wan, Xiaoli Du, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Insights into the Interaction of Lysosomal Amino Acid Transporters SLC38A9 and SLC36A1 Involved in mTORC1 Signaling in C2C12 Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomolecules (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/biom11091314"}], "href": "https://doi.org/10.3390/biom11091314"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34572527"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34572527"}]}]}]}