| HGNC Family | Non-coding RNAs |
| Name | small nucleolar RNA, H/ACA box 73B |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSNORA73B (as characterized in recent investigations) is significantly upregulated in psoriasis patient samples and plays a critical role in promoting the progression of this immune-mediated skin disease. Functionally, SNORA73B enhances both cell proliferation and migration, which are key processes in the pathogenesis of psoriasis. Mechanistic studies indicate that SNORA73B acts as a molecular sponge for miR-3074-5p, thereby releasing its inhibitory effects on the transcription factor PBX1. The derepression of PBX1 then contributes to the augmented cellular behaviors observed in psoriasis, outlining a novel SNORA73B/miR-3074-5p/PBX1 signaling axis that may serve as a promising target for therapeutic intervention."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lihua Zhang, Hui Guo, Xiaoguang Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Small nucleolar RNA Snora73 promotes psoriasis progression by sponging miR-3074-5p and regulating PBX1 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Funct Integr Genomics (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10142-024-01300-7"}], "href": "https://doi.org/10.1007/s10142-024-01300-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38240925"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38240925"}]}]}]}
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| Synonyms | 105A, U17B, RNU105A, RNU17B, E1C |
| NCBI Gene ID | 26768 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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SNORA73B has 681 functional associations with biological entities spanning 4 categories (functional term, phrase or reference, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 7 datasets.
Click the + buttons to view associations for SNORA73B from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing SNORA73B from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of SNORA73B gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of SNORA73B gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of SNORA73B gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of SNORA73B gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of SNORA73B gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of SNORA73B gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
