{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSNORA74B is a small nucleolar RNA that plays a significant oncogenic role in gallbladder cancer. Elevated levels of SNORA74B in tumor tissues are positively correlated with key indicators of aggressive disease, including local invasion, advanced TNM stage, increased CA19-9 levels, and high Ki67 expression. Mechanistically, SNORA74B appears to suppress the expression of PHLPP, an endogenous inhibitor of the AKT/mTOR pathway, thereby promoting cell proliferation and survival. Functionally, silencing SNORA74B in gallbladder cancer cells leads to reduced cell growth, induction of G1 cell cycle arrest, and increased apoptosis—effects that are mediated by restored PHLPP activity and consequent inhibition of the AKT/mTOR signaling cascade. These findings suggest that SNORA74B may serve as a potential therapeutic target in gallbladder cancer treatment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yiyu Qin, Li Meng, Yang Fu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SNORA74B gene silencing inhibits gallbladder cancer cells by inducing PHLPP and suppressing Akt/mTOR signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.15301"}], "href": "https://doi.org/10.18632/oncotarget.15301"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28212545"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28212545"}]}]}]}