{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have provided intriguing insights into brain-expressed molecules that shape neurophysiological processes, as exemplified by detailed examinations of BAI2. In one study, proteolytic processing of BAI2 at its GPCR proteolysis site (GPS) was shown to be essential for receptor activation, with cleaved C-terminal fragments specifically triggering the NFAT pathway, thereby suggesting a tightly regulated mechanism for BAI2 function in the brain."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \nAnother line of investigation revealed that BAI2 plays a regulatory role in controlling vascular endothelial growth factor (VEGF) transcription. This study demonstrated that BAI2 interacts with GA-binding protein subunits (GABPα/γ), acting as a transcriptional repressor of VEGF expression both under normal conditions and during cerebral ischemia."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n \nA separate genetic analysis employing ENU mutagenesis uncovered a hyperactivity phenotype in mice that was linked to a missense mutation (R619W) in BAI2. This mutation, which diminishes the receptor’s surface expression in mammalian cells, underscores the importance of proper BAI2 localization and function for normal behavioral phenotypes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n \nIt is important to note that although these abstracts offer considerable detail on the various roles of BAI2 in neural processes, none of them address or provide functional insights into SNORA80A. SNORA80A, as a small nucleolar RNA typically involved in guiding RNA modifications, does not feature in these studies. Consequently, while the mechanistic and biological actions of BAI2 have been well characterized in these works, the function of SNORA80A remains unexplored within this context.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Daisuke Okajima, Gen Kudo, Hiroshi Yokota "}, {"type": "b", "children": [{"type": "t", "text": "Brain-specific angiogenesis inhibitor 2 (BAI2) may be activated by proteolytic processing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Recept Signal Transduct Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3109/10799891003671139"}], "href": "https://doi.org/10.3109/10799891003671139"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20367554"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20367554"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Byung Chul Jeong, Mi-Young Kim, Ji Hee Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Brain-specific angiogenesis inhibitor 2 regulates VEGF through GABP that acts as a transcriptional repressor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2005.12.086"}], "href": "https://doi.org/10.1016/j.febslet.2005.12.086"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16412436"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16412436"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "David J Speca, James S Trimmer, Andrew S Peterson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Whole exome sequencing reveals a functional mutation in the GAIN domain of the Bai2 receptor underlying a forward mutagenesis hyperactivity QTL."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mamm Genome (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00335-017-9716-5"}], "href": "https://doi.org/10.1007/s00335-017-9716-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28894906"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28894906"}]}]}]}