{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nA careful review of the provided abstracts reveals that none of these studies mention or investigate SNORA80B. Instead, the articles focus on various aspects of CD40‐mediated signaling in immune cells—including its role in CD4 help for CD8+ memory differentiation, dendritic cell licensing, NF‑κB activation, and the regulation of both innate and adaptive immune responses in contexts ranging from autoimmunity to cancer immunotherapy. In contrast, SNORA80B—a small nucleolar RNA typically implicated in the post‑transcriptional modification of ribosomal or other small RNAs—is not addressed, and no functional data linking it to any CD40‐related process is provided."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "35"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn summary, while the collected studies robustly explore the multifaceted roles of the CD40/CD40L axis in immune cell activation, tolerance, and disease pathogenesis, they do not provide any insight into the function of SNORA80B. Thus, within the context of this literature, no direct association can be drawn between SNORA80B and the immune regulatory mechanisms discussed—and the functional relevance of SNORA80B remains to be elucidated in other studies."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "35"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Andrew S MacDonald, Amy D Straw, Nicole M Dalton, et al. 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