SNORA80E Gene

HGNC Family Non-coding RNAs
Name small nucleolar RNA, H/ACA box 80E
Description Predicted to be involved in RNA processing. Predicted to be located in nucleolus. [provided by Alliance of Genome Resources, Mar 2025]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSNORA42, a small nucleolar RNA, has emerged as an oncogenic driver in a variety of human cancers. In non‐small cell lung cancer (NSCLC), SNORA42 is frequently overexpressed through genomic amplification—independent of its host gene—and its heightened expression correlates with increased cell proliferation, colony formation, and reduced apoptosis in a p53‐dependent manner. In parallel, systematic evaluations in colorectal cancer have underscored the clinical importance and biomarker potential of dysregulated snoRNAs, including SNORA42, in tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn prostate cancer, SNORA42 is up-regulated—further induced by dihydrotestosterone—and contributes to enhanced cellular proliferation, migration, invasion, and resistance to apoptosis, with its overexpression predicting poorer outcomes in metastatic contexts. Similarly, in esophageal squamous cell carcinoma, elevated SNORA42 levels drive tumor progression by stabilizing the RNA helicase DHX9, thereby promoting NF-κB signaling through the DHX9/p65 axis and stimulating both cell growth and metastatic potential."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nA comprehensive systematic review further supports SNORA42 as a critical contributor to carcinogenesis, highlighting its promise not only as a diagnostic and prognostic biomarker but also as a potential therapeutic target across multiple tumor types."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Y-P Mei, J-P Liao, J Shen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Small nucleolar RNA 42 acts as an oncogene in lung tumorigenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2011.449"}], "href": "https://doi.org/10.1038/onc.2011.449"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21986946"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21986946"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yoshinaga Okugawa, Yuji Toiyama, Shusuke Toden, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinical significance of SNORA42 as an oncogene and a prognostic biomarker in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gut (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/gutjnl-2015-309359"}], "href": "https://doi.org/10.1136/gutjnl-2015-309359"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26475630"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26475630"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Chuanyou Yi, Xuechao Wan, Yufeng Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SNORA42 enhances prostate cancer cell viability, migration and EMT and is correlated with prostate cancer poor prognosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biochem Cell Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biocel.2018.07.009"}], "href": "https://doi.org/10.1016/j.biocel.2018.07.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30053504"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30053504"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yanan Shan, Sisi Wei, Xiaohan Xiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SNORA42 promotes oesophageal squamous cell carcinoma development through triggering the DHX9/p65 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genomics (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ygeno.2021.06.036"}], "href": "https://doi.org/10.1016/j.ygeno.2021.06.036"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34182081"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34182081"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Eldevan Da Silva Barbosa, Ana Gabrielly De Melo Matos, Marcelli Geisse De Oliveira Prata Da Silva, et al. "}, {"type": "b", "children": [{"type": "t", "text": "What is the Role of SNORA42 in Carcinogenesis? A Systematic Review."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Asian Pac J Cancer Prev (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.31557/APJCP.2023.24.7.2217"}], "href": "https://doi.org/10.31557/APJCP.2023.24.7.2217"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37505750"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37505750"}]}]}]}
Synonyms ACA42, SNORA42
NCBI Gene ID 677823
API
Download Associations
Predicted Functions View SNORA80E's ARCHS4 Predicted Functions.
Co-expressed Genes View SNORA80E's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View SNORA80E's ARCHS4 Predicted Functions.

Functional Associations

SNORA80E has 623 functional associations with biological entities spanning 5 categories (molecular profile, functional term, phrase or reference, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 15 datasets.

Click the + buttons to view associations for SNORA80E from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of SNORA80E gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of SNORA80E gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of SNORA80E gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at SNORA80E gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of SNORA80E gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of SNORA80E gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with SNORA80E gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of SNORA80E gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations kinase perturbations changing expression of SNORA80E gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of SNORA80E gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of SNORA80E gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of SNORA80E gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of SNORA80E gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of SNORA80E gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
TCGA Signatures of Differentially Expressed Genes for Tumors tissue samples with high or low expression of SNORA80E gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.