SNORA81 Gene

HGNC Family Non-coding RNAs
Name small nucleolar RNA, H/ACA box 81
Description Small nucleolar RNAs (snoRNAs) are small noncoding RNAs involved in RNA processing. Box H/ACA snoRNAs, such as SNORA81, direct the conversion of uridine to pseudouridine at specific residues of ribosomal RNAs or small nuclear RNAs (snRNAs) (Gu et al., 2005).[supplied by OMIM, Mar 2008]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe study (1) describes the discovery of AGT1/SLC7A13 as the novel partner of rBAT in the kidney’s S3 proximal tubule segment. In these cells, rBAT forms a heterodimer with AGT1 to facilitate the transport of cystine, along with aspartate and glutamate, thereby playing a critical role in preventing the urinary loss of these amino acids. This work elucidates that, in the absence of rBAT, AGT1 expression is lost, underscoring the functional interdependence of the two proteins in renal amino acid reabsorption and in protecting against cystinuria. It should be noted that, although the initial request was to summarize the function of SNORA81, the provided abstract (1) does not mention or characterize SNORA81, leaving its function undiscussed within the context of this study."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shushi Nagamori, Pattama Wiriyasermkul, Meritxell Espino Guarch, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel cystine transporter in renal proximal tubule identified as a missing partner of cystinuria-related plasma membrane protein rBAT/SLC3A1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1519959113"}], "href": "https://doi.org/10.1073/pnas.1519959113"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26739563"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26739563"}]}]}]}
Synonyms HBI-61
NCBI Gene ID 677847
API
Download Associations
Predicted Functions View SNORA81's ARCHS4 Predicted Functions.
Co-expressed Genes View SNORA81's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View SNORA81's ARCHS4 Predicted Functions.

Functional Associations

SNORA81 has 1,593 functional associations with biological entities spanning 5 categories (molecular profile, chemical, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 18 datasets.

Click the + buttons to view associations for SNORA81 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of SNORA81 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of SNORA81 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of SNORA81 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of SNORA81 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at SNORA81 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of SNORA81 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of SNORA81 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of SNORA81 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of SNORA81 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of SNORA81 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of SNORA81 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of SNORA81 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles cell lines with high or low expression of SNORA81 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of SNORA81 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of SNORA81 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at SNORA81 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
TCGA Signatures of Differentially Expressed Genes for Tumors tissue samples with high or low expression of SNORA81 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.
WikiPathways Pathways 2014 pathways involving SNORA81 protein from the Wikipathways Pathways 2014 dataset.