{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed that hormonal signaling via abscisic acid (ABA) and its receptor LANCL2 orchestrates key inflammatory responses in immune cells. For example, inhaled quartz stimulates murine and rat macrophages to release ABA, which acts in an autocrine manner via LANCL2 to trigger downstream signals such as Ca²⁺ influx and NFκB activation, resulting in increased inflammatory mediators like prostaglandin-E₂ and TNF-α. In addition, computational and in vivo studies of Helicobacter pylori infection show that LANCL2 critically regulates the balance between pro‐inflammatory and regulatory responses in macrophages and T cells, thereby allowing persistent bacterial colonization while protecting the epithelium from damage."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the realm of metabolic regulation, LanC-like proteins have been examined for roles beyond their traditionally presumed catalytic functions. Although initial proposals regarding their involvement in lanthionine biosynthesis were not substantiated in knockout mouse models, further investigations have identified LANCL2 as a positive regulator of adipogenesis through its direct interaction with the nuclear receptor PPARγ, thereby supporting the transcription of key adipogenic genes. Moreover, the ABA/LANCL system has been shown to modulate mitochondrial activity and thermogenesis in both white and brown adipocytes via the AMPK/PGC-1α/Sirt1/ERRα signaling axis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn contrast to the mechanistic insights provided by studies on the ABA/LANCL pathway, recent biomarker discovery efforts in non‐small‐cell lung cancer (NSCLC) have focused on plasma small nucleolar RNAs (snoRNAs). Among these, SNORD111 has emerged as a promising candidate for early-stage NSCLC diagnostics. Although its precise biological function remains to be fully defined, SNORD111—as with other snoRNAs—may serve as an indicator of the dysregulated cellular processes, including those related to inflammation and metabolism, that are modulated by factors such as the ABA/LANCL system."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Mirko Magnone, Laura Sturla, Emanuela Jacchetti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Autocrine abscisic acid plays a key role in quartz-induced macrophage activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.11-187351"}], "href": "https://doi.org/10.1096/fj.11-187351"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22042223"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22042223"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Andrew Leber, Josep Bassaganya-Riera, Nuria Tubau-Juni, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Modeling the Role of Lanthionine Synthetase C-Like 2 (LANCL2) in the Modulation of Immune Responses to Helicobacter pylori Infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0167440"}], "href": "https://doi.org/10.1371/journal.pone.0167440"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27936058"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27936058"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Chang He, Min Zeng, Debapriya Dutta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LanCL proteins are not Involved in Lanthionine Synthesis in Mammals."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep40980"}], "href": "https://doi.org/10.1038/srep40980"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28106097"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28106097"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Debapriya Dutta, Kuan-Yu Lai, Adriana Reyes-Ordoñez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lanthionine synthetase C-like protein 2 (LanCL2) is important for adipogenic differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Lipid Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1194/jlr.M085274"}], "href": "https://doi.org/10.1194/jlr.M085274"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29880530"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29880530"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Sonia Spinelli, Vanessa Cossu, Mario Passalacqua, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The ABA/LANCL1/2 Hormone/Receptor System Controls Adipocyte Browning and Energy Expenditure."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms24043489"}], "href": "https://doi.org/10.3390/ijms24043489"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36834900"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36834900"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Kangyu Wang, Xingguo Song, Shiwen Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Plasma SNORD42B and SNORD111 as potential biomarkers for early diagnosis of non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Lab Anal (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcla.24740"}], "href": "https://doi.org/10.1002/jcla.24740"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36284435"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36284435"}]}]}]}