SNORD113-1 Gene

HGNC Family Non-coding RNAs
Name small nucleolar RNA, C/D box 113-1
Description Small nucleolar RNAs (snoRNAs), like SNORD113-1, guide the formation of 2-prime O-methylation of ribosomal RNA (rRNA) and U small nuclear RNAs (snRNAs) through a specific RNA duplex at each modification site. SNORD113-1 is 1 of 9 tandem SNORD113 genes on chromosome 14q32 (Cavaille et al., 2002 [PubMed 12045206]).[supplied by OMIM, Nov 2010]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nEmerging evidence supports that small nucleolar RNAs (snoRNAs) play critical roles in tumorigenesis by modulating cellular processes though their precise mechanisms remain to be fully elucidated. In this context, SNORD113-1 has been spotlighted as a snoRNA of interest in hepatocellular carcinoma (HCC), yet its specific regulatory functions in this cancer type have not been determined."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThe current understanding implies that while numerous snoRNAs contribute to vital aspects of cellular homeostasis and gene regulation, SNORD113-1 represents an intriguing candidate whose aberrant expression may underlie pro-tumorigenic processes in HCC. Its potential involvement in controlling pathways related to cell proliferation or survival highlights the need to further investigate its molecular targets and downstream effects."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nContinued research into SNORD113-1 is essential to define its mechanistic contributions to liver cancer development. Such studies might not only refine our understanding of snoRNA-mediated regulation in oncogenesis but also pave the way for identifying novel biomarkers or therapeutic targets for hepatocellular carcinoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Gang Xu, Fang Yang, Cui-Ling Ding, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Small nucleolar RNA 113-1 suppresses tumorigenesis in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1476-4598-13-216"}], "href": "https://doi.org/10.1186/1476-4598-13-216"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25217841"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25217841"}]}]}]}
Synonyms 14Q(I-1)
NCBI Gene ID 767561
API
Download Associations
Predicted Functions View SNORD113-1's ARCHS4 Predicted Functions.
Co-expressed Genes View SNORD113-1's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View SNORD113-1's ARCHS4 Predicted Functions.

Functional Associations

SNORD113-1 has 189 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 11 datasets.

Click the + buttons to view associations for SNORD113-1 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of SNORD113-1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of SNORD113-1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of SNORD113-1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of SNORD113-1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at SNORD113-1 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of SNORD113-1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of SNORD113-1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of SNORD113-1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of SNORD113-1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of SNORD113-1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at SNORD113-1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.