{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nEmerging evidence suggests that SNORD113-2, a member of the C/D box small nucleolar RNA family, might play an indirect role in fine‐tuning posttranscriptional regulatory events in differentiated cells. In muscle fiber formation, for example, the timely stabilization of key myogenic mRNAs—mediated by the RNA‐binding protein HuR—depends on the regulated intracellular trafficking of such factors. Although SNORD113-2 is not explicitly mentioned in this context, its established role in ribonucleoprotein complex formation raises the intriguing possibility that it could contribute to the modulation of HuR’s function, thereby impacting the nuclear import dynamics orchestrated by Transportin 2 (TRN2) and influencing myogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \nDisruption of precise nucleocytoplasmic transport is also at the heart of Hedgehog (Hh) pathway regulation where the localization of Gli transcription factors to primary cilia is critical for pathway activation. In this model, a nuclear import system based on the PY-type nuclear localization signal and karyopherinβ2 (Kapβ2) ensures proper Gli trafficking. Although the direct involvement of SNORD113-2 is yet to be established, the RNA modifications and RNP assembly functions commonly attributable to snoRNAs like SNORD113-2 might influence the stability or efficiency of these transport processes, thereby modulating Hh signal transduction in both developmental and disease contexts."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n\nIntegrating these insights, it is plausible to consider that SNORD113-2 could serve as a regulatory RNA that indirectly shapes cellular differentiation and signaling pathways by influencing the assembly or function of ribonucleoprotein complexes. Whether by modulating the posttranscriptional stabilization of mRNAs critical for myofiber formation or by fine-tuning the nuclear import machinery essential for Gli activation in Hedgehog signaling, SNORD113-2 represents a promising candidate for further mechanistic studies in the context of differentiated cell functions and oncogenic processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kate van der Giessen, Imed-Eddine Gallouzi "}, {"type": "b", "children": [{"type": "t", "text": "Involvement of transportin 2-mediated HuR import in muscle cell differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e07-02-0167"}], "href": "https://doi.org/10.1091/mbc.e07-02-0167"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17475777"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17475777"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yuhong Han, Yue Xiong, Xuanming Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of Gli ciliary localization and Hedgehog signaling by the PY-NLS/karyopherin-β2 nuclear import system."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pbio.2002063"}], "href": "https://doi.org/10.1371/journal.pbio.2002063"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28777795"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28777795"}]}]}]}