{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe first study (PMID:"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "investigated a mouse odorant receptor, SR1, which exhibits an unusually broad responsiveness to a wide range of structurally diverse odorants. The work highlights the traditional view that most olfactory receptors are narrowly tuned; however, SR1 defies this model by being highly promiscuous in its interactions. Notably, while the study provides comprehensive insights into receptor function and signal detection, it does not directly assign any role or function to SNORD114‑28.\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThe second study (PMID:"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "focused on the molecular activation mechanisms of odorant receptors, using a combination of site‐directed mutagenesis, heterologous expression, and computational simulations to identify key structural motifs involved in receptor activation. Although the work elucidates vital components such as the toggle switch and ionic lock that underpin receptor signaling, SNORD114‑28 was not mentioned in the analysis or discussion of receptor functionality.\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nTaken together, these abstracts advance our understanding of the molecular and functional diversity within the olfactory receptor family, underscoring mechanisms that enable broad odorant detection and receptor activation. However, they provide no evidence of a direct role for SNORD114‑28 in these processes. As such, the function of SNORD114‑28 remains uncharacterized in the context of these studies and awaits further investigation to determine whether it may have regulatory or other ancillary roles in olfactory biology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xavier Grosmaitre, Stefan H Fuss, Anderson C Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SR1, a mouse odorant receptor with an unusually broad response profile."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.2752-09.2009"}], "href": "https://doi.org/10.1523/JNEUROSCI.2752-09.2009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19923288"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19923288"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Claire A de March, Yiqun Yu, Mengjue J Ni, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Conserved Residues Control Activation of Mammalian G Protein-Coupled Odorant Receptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Chem Soc (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/jacs.5b04659"}], "href": "https://doi.org/10.1021/jacs.5b04659"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26090619"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26090619"}]}]}]}