{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough none of the three abstracts directly mention SNORD115-16, the studies collectively provide insight into key mechanisms of glycogen synthesis and storage in muscle and lung tissues that may serve as a pertinent framework for exploring potential RNA‐mediated regulatory roles. In the first study, glycogenin deficiency in mice paradoxically leads to high muscle glycogen accumulation with altered metabolic profiles and reduced endurance, implying that the regulatory network governing glycogen synthesis may tolerate alternative initiation pathways (as shown in."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThe second study employs targeted inhibition of major enzymes responsible for glycogen assembly in a Pompe disease model, demonstrating that suppression of glycogen synthesis via glycogenin and glycogen synthase can ameliorate pathological glycogen storage and lysosomal enlargement. This therapeutic approach underscores the importance of fine-tuning glycogen metabolism in muscle tissues."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the third study, the absence of glycogen in the lungs of glycogenin- or glycogen synthase-deficient mice is linked to reduced levels and impaired processing of critical surfactant proteins, resulting in high neonatal mortality due to respiratory distress. This finding highlights the essential role of glycogen as a substrate reservoir during lung maturation and the perinatal surge in surfactant production."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " While these studies focus on protein enzymes and substrates central to glycogen metabolism, they raise the possibility that noncoding RNAs—including small nucleolar RNAs like SNORD115-16—could contribute to the regulation of these metabolic pathways through post-transcriptional processes. However, further research is needed to specifically delineate any functional connection between SNORD115-16 and the regulation of glycogen synthesis and utilization in these tissues.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Giorgia Testoni, Jordi Duran, Mar García-Rocha, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lack of Glycogenin Causes Glycogen Accumulation and Muscle Function Impairment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Metab (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cmet.2017.06.008"}], "href": "https://doi.org/10.1016/j.cmet.2017.06.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28683291"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28683291"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Gaelle Douillard-Guilloux, Nina Raben, Shoichi Takikita, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Modulation of glycogen synthesis by RNA interference: towards a new therapeutic approach for glycogenosis type II."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddn290"}], "href": "https://doi.org/10.1093/hmg/ddn290"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18782850"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18782850"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Giorgia Testoni, Bárbara Olmeda, Jordi Duran, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pulmonary glycogen deficiency as a new potential cause of respiratory distress syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddaa249"}], "href": "https://doi.org/10.1093/hmg/ddaa249"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33219378"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33219378"}]}]}]}