{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe current body of work rigorously characterizes the platelet glycoprotein Ib‐IX‐V complex as an essential receptor for von Willebrand factor, mediating platelet adhesion, activation, and aggregation. In one study, the endoplasmic reticulum chaperone gp96 (also known as grp94/HSP90b1) was found to be indispensable for proper assembly of this complex through its selective binding to the GPIX subunit—a discovery that has shed new light on the molecular basis of Bernard‐Soulier syndrome and related thrombocytopenias."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional investigations in both infectious and inflammatory settings have demonstrated that disruptions or modifications of the GPIb-IX complex can significantly impact platelet function. For instance, in models of sepsis and endotoxemia, the receptor has been implicated in mediating platelet adhesion to damaged endothelium, thereby contributing to intravascular inflammation, microvascular thrombosis, and thrombocytopenia."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nInterestingly, none of the studies summarized above include or reference SNORD115-17. SNORD115-17 is a small nucleolar RNA typically associated with the post‐transcriptional modification and processing of RNA transcripts. Its established functions—such as modulating alternative splicing events (for example, in other contexts like the regulation of serotonin receptor 2C pre-mRNA)—are not connected to the molecular assembly, signaling, or functional roles of the GPIb-IX-V complex described in these investigations."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Matthew Staron, Shuang Wu, Feng Hong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Heat-shock protein gp96/grp94 is an essential chaperone for the platelet glycoprotein Ib-IX-V complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2011-01-330464"}], "href": "https://doi.org/10.1182/blood-2011-01-330464"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21576699"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21576699"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Catherine Strassel, Anita Eckly, Catherine Léon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Intrinsic impaired proplatelet formation and microtubule coil assembly of megakaryocytes in a mouse model of Bernard-Soulier syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Haematologica (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3324/haematol.2008.001032"}], "href": "https://doi.org/10.3324/haematol.2008.001032"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19377075"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19377075"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Adam Corken, Susan Russell, Judith Dent, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Role for platelet glycoprotein Ib-IX and effects of its inhibition in endotoxemia-induced thrombosis, thrombocytopenia, and mortality."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arterioscler Thromb Vasc Biol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/ATVBAHA.113.302339"}], "href": "https://doi.org/10.1161/ATVBAHA.113.302339"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24051142"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24051142"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "M Keegan Delaney, Junling Liu, Yi Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The role of Rac1 in glycoprotein Ib-IX-mediated signal transduction and integrin activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arterioscler Thromb Vasc Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/ATVBAHA.112.254920"}], "href": "https://doi.org/10.1161/ATVBAHA.112.254920"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22995516"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22995516"}]}]}]}