{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe study (1) characterizes a novel neural C1q‐like protein 2 (nCLP2) that is selectively expressed in the central nervous system. nCLP2 forms disulphide‐bonded multimers and is targeted specifically to brain regions involved in memory formation—the hippocampus, entorhinal cortex, anterodorsal thalamic nucleus—and the retina. Its presence in mossy fibre axons, as well as in synaptic boutons and clefts, suggests that nCLP2 is anterogradely transported and secreted from presynaptic termini, implicating it in the organization, function, and maintenance of synapses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "While the provided abstract does not directly discuss SNORD115-18, it is worth noting that SNORD115-18 is a member of the small nucleolar RNA family typically involved in the chemical modification and processing of other RNA molecules. In other contexts, snoRNAs like SNORD115-18 have been implicated in the regulation of alternative splicing and gene expression. However, its specific role in the central nervous system or its potential interplay with proteins such as nCLP2 remains to be elucidated."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chisei Shimono, Ri-Ichiroh Manabe, Tomiko Yamada, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification and characterization of nCLP2, a novel C1q family protein expressed in the central nervous system."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biochem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jb/mvp203"}], "href": "https://doi.org/10.1093/jb/mvp203"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19996152"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19996152"}]}]}]}