{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nA careful review of the provided literature indicates that none of the abstracts address SNORD115-30. Instead, these studies concentrate on the multifaceted immunoregulatory roles of CD84—a signaling lymphocyte activation molecule (SLAM) family receptor—across diverse disease models. For example, one study demonstrated that CD84 is broadly expressed on mouse immune cells and modulates intracellular signaling pathways downstream of Toll‐like receptors, thereby influencing cytokine secretion and inflammatory responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOther reports have established that CD84 is critical for adaptive immune regulation. Its expression on B and T lymphocytes affects germinal center formation and B cell tolerance, as evidenced in autoimmune models and in contexts such as chronic lymphocytic leukemia and multiple myeloma, where it helps mediate interactions between malignant cells and their microenvironment. Moreover, genetic disruption experiments imply that although CD84 and related SLAM family receptors modulate T–B cell conjugation and autoantibody generation, redundancy among these receptors may preserve overall germinal center responses."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its immunoregulatory roles, CD84 is implicated in tissue-specific pathological processes. Studies highlight its contribution to thromboinflammatory mechanisms following ischemic stroke and its participation in microglial activation during spinal cord injury, where regulatory RNA networks can modulate its expression to affect neuronal survival. Further, in infectious disease settings such as tuberculosis, elevated CD84 levels are associated with immune suppression, suggesting that targeting CD84 may offer a novel checkpoint immunotherapy approach."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jordi Sintes, Xavier Romero, Jose de Salort, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mouse CD84 is a pan-leukocyte cell-surface molecule that modulates LPS-induced cytokine secretion by macrophages."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Leukoc Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1189/jlb.1109756"}], "href": "https://doi.org/10.1189/jlb.1109756"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20628063"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20628063"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "S Hofmann, T Vögtle, M Bender, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The SLAM family member CD84 is regulated by ADAM10 and calpain in platelets."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Thromb Haemost (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jth.12013"}], "href": "https://doi.org/10.1111/jth.12013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23025437"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23025437"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Takuma Fujii, Rong Hou, Aya Sato-Hayashizaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Susceptibility loci for the defective foreign protein-induced tolerance in New Zealand Black mice: implication of epistatic effects of Fcgr2b and Slam family genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Immunol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/eji.201141552"}], "href": "https://doi.org/10.1002/eji.201141552"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21604261"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21604261"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Sebastian Hofmann, Attila Braun, Rastislav Pozgaj, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mice lacking the SLAM family member CD84 display unaltered platelet function in hemostasis and thrombosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0115306"}], "href": "https://doi.org/10.1371/journal.pone.0115306"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25551754"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25551754"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Eric B Wong, Chetna Soni, Alice Y Chan, et al. 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