{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nWhile none of the provided abstracts directly address SNORD115‐44, they offer detailed insights into the functions of the BRE gene and its associated proteins, which collectively play pivotal roles in modulating cellular stress responses. Notably, BRE (also known as BRCC45) has been shown to influence cell survival and apoptosis through interactions with key regulators such as p53, NF‑κB, and XIAP. In particular, BRE knockdown or overexpression leads to marked changes in proteins that control proliferation and survival, thereby affecting tumor growth and stress‐induced cell death."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional studies demonstrate that BRE is critically involved in the maintenance of genomic integrity. BRE‐deficient cells exhibit impaired DNA repair, as evidenced by prolonged γ‑H2AX foci and disrupted recruitment of the BRCA1‑A complex during homologous recombination. Moreover, BRE levels impact cellular senescence and modulate osteogenic differentiation; reduced BRE expression correlates with deteriorated osteoblast function and altered bone remodeling through an upregulation of p53 signaling pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, research on Babam2—a protein within the same BRISC/BRCA1‑A complex network—reveals its role as a negative regulator of osteoclast formation and bone resorption. Babam2 appears to act through interactions with transcriptional regulators like Hey1, ultimately attenuating the activity of Nfatc1 and mitigating osteoclast‐mediated bone loss. This finding underscores a broader regulatory network in which BRE and its associated factors contribute not only to stress and apoptotic responses but also to bone homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn summary, although the function of SNORD115‐44 is not delineated in these studies, the collective data highlight critical roles for BRE and related proteins in controlling cellular stress responses, DNA repair, apoptosis, and bone remodeling. Future research may reveal whether SNORD115‐44 intersects with these regulatory pathways, enhancing our understanding of its potential biological significance.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Arthur Kar Keung Ching, Qing Li, Pak Leong Lim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of a conserved mouse stress-modulating gene, Bre: comparison with the human ortholog."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "DNA Cell Biol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/10445490360708900"}], "href": "https://doi.org/10.1089/10445490360708900"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14565866"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14565866"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Mei Kuen Tang, Chun Mei Wang, Sze Wan Shan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comparative proteomic analysis reveals a function of the novel death receptor-associated protein BRE in the regulation of prohibitin and p53 expression and proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proteomics (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/pmic.200500603"}], "href": "https://doi.org/10.1002/pmic.200500603"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16518872"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16518872"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yiu-Loon Chui, Chun-Hung Ma, Wei Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Anti-apoptotic protein BRE/BRCC45 attenuates apoptosis through maintaining the expression of caspase inhibitor XIAP in mouse Lewis lung carcinoma D122 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Apoptosis (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10495-013-0963-y"}], "href": "https://doi.org/10.1007/s10495-013-0963-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24395041"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24395041"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Wenting Shi, Mei Kuen Tang, Yao Yao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BRE plays an essential role in preventing replicative and DNA damage-induced premature senescence."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep23506"}], "href": "https://doi.org/10.1038/srep23506"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27001068"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27001068"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Fujun Jin, Yiliang Wang, Xiaojing Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bre Enhances Osteoblastic Differentiation by Promoting the Mdm2-Mediated Degradation of p53."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cells (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/stem.2620"}], "href": "https://doi.org/10.1002/stem.2620"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28436570"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28436570"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Fujun Jin, Yexuan Zhu, Meijing Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Babam2 negatively regulates osteoclastogenesis by interacting with Hey1 to inhibit Nfatc1 transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biol Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/ijbs.72487"}], "href": "https://doi.org/10.7150/ijbs.72487"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35864959"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35864959"}]}]}]}