SNORD115-5 Gene

HGNC Family Non-coding RNAs
Name small nucleolar RNA, C/D box 115-5
Description Predicted to be involved in RNA processing. Predicted to be located in nucleolus. [provided by Alliance of Genome Resources, Mar 2025]
Summary
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In various contexts—ranging from the control of invasive fungal pathogens (e.g. Aspergillus fumigatus, Candida albicans, Coccidioides spp.) to modulation of antitumor immunity and regulation of allergic or autoimmune inflammation—Dectin‐1 acts in synergy with other receptors (including Toll–like receptors and complement receptors) to fine‐tune the host immune response."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurther studies in this collection extend the understanding of Dectin‐1’s contributions—highlighting its cooperation with complement receptors, its influence on dendritic cell function and T‐cell polarization, its regulation by cytokines, and its involvement in lipid raft recruitment that is essential for proper signaling and cell function. Despite these extensive insights into innate immune signaling and fungal recognition, none of the abstracts address SNORD115‐5, a small nucleolar RNA typically implicated in RNA modification and alternative splicing regulation. Thus, while Dectin‐1’s multifaceted role in orchestrating immune responses is well documented."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "21", "end_ref": "42"}]}, {"type": "t", "text": " In summary, while these abstracts richly describe Dectin‐1’s role in immune surveillance and host defense, they do not provide any data on SNORD115‐5; hence, its function in the contexts studied remains unaddressed and would require separate investigation.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Philip R Taylor, Gordon D Brown, Delyth M Reid, et al. 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Synonyms HBII-52-5
NCBI Gene ID 100033442
API
Download Associations
Predicted Functions View SNORD115-5's ARCHS4 Predicted Functions.
Co-expressed Genes View SNORD115-5's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View SNORD115-5's ARCHS4 Predicted Functions.

Functional Associations

SNORD115-5 has 175 functional associations with biological entities spanning 4 categories (molecular profile, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 10 datasets.

Click the + buttons to view associations for SNORD115-5 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of SNORD115-5 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of SNORD115-5 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
CTD Gene-Chemical Interactions chemicals interacting with SNORD115-5 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at SNORD115-5 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of SNORD115-5 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of SNORD115-5 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of SNORD115-5 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of SNORD115-5 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of SNORD115-5 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at SNORD115-5 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.