{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nA review of the compiled literature reveals that many of these studies investigate key regulatory proteins and signaling networks—most notably the epithelial cell adhesion molecule (EpCAM) and its associated partners—in processes such as liver regeneration and development, bile acid homeostasis, tight junction integrity, cellular proliferation, differentiation, and immune cell migration."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional works in this collection focus on broader aspects of cell cycle control, post‐transcriptional regulation, and signaling pathway modulation—including Hippo, immune receptor, and proteolytic cascades in a variety of tissues and neoplastic contexts."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nNotably, however, none of these abstracts provides any direct insight into the biological function of SNORD117. Despite the extensive characterization of protein–protein interactions, adhesion molecules, and noncoding regulators in these studies"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "21", "end_ref": "39"}]}, {"type": "t", "text": ", there is no mention or experimental evaluation of SNORD117. As a member of the C/D box small nucleolar RNAs typically known to guide 2′-O-methylation modifications of rRNAs and other RNAs, any role for SNORD117 in these contexts remains to be elucidated. In summary, while these studies deepen our understanding of cellular adhesion, differentiation, and signaling networks, dedicated research is needed to determine whether SNORD117 participates in ribonucleoprotein complex assembly, RNA modification, or other regulatory pathways in either normal physiology or disease states.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Eva Schmelzer, Lola M Reid "}, {"type": "b", "children": [{"type": "t", "text": "EpCAM expression in normal, non-pathological tissues."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Biosci (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2741/2911"}], "href": "https://doi.org/10.2741/2911"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17981779"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17981779"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Monika Trzpis, Eliane R Popa, Pamela M J McLaughlin, et al. 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