{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe provided abstract (PMID"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "details how cells adapt to hypoxia by reprogramming glucose metabolism. Under low oxygen conditions, hypoxia‐inducible factors (HIFs) trigger the transcriptional upregulation of key enzymes involved in glycogen biosynthesis—most notably, muscle glycogen synthase (GYS1) along with UGP2 and GBE1—thereby leading to increased glycogen accumulation. The study demonstrates that HIF-mediated induction of GYS1 not only elevates glycogen synthase activity but also supports the cell’s capacity for hypoxic preconditioning, underlining the central role of this metabolic shift in cellular adaptation.\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIt is important to note that the provided abstract does not mention the small nucleolar RNA SNORD14A, and therefore no functional information on SNORD14A can be derived from this source. Further investigation of other studies would be required to elucidate the role of SNORD14A in cellular processes.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Nuria Pescador, Diego Villar, Daniel Cifuentes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hypoxia promotes glycogen accumulation through hypoxia inducible factor (HIF)-mediated induction of glycogen synthase 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0009644"}], "href": "https://doi.org/10.1371/journal.pone.0009644"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20300197"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20300197"}]}]}]}