{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSNORD15B is one of the small nucleolar RNAs (snoRNAs), a family of noncoding RNAs that typically guide the site‐specific modification of ribosomal RNA and other RNA species. Although the study described in PMID"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "focused on a subset of SNORDs (specifically the SNORD115 and SNORD116 clusters) in the context of Alzheimer’s disease (AD), its findings underscore the emerging significance of snoRNAs as potential biomarkers. By mediating RNA modifications, members of the SNORD family – including SNORD15B – may influence diverse cellular processes such as ribosome biogenesis and post‐transcriptional regulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "In this study, plasma‐derived extracellular vesicles from AD patients were found to be enriched in specific snoRNAs compared to cognitively normal controls. While the report highlights alterations in SNORD115 and SNORD116, by association, SNORD15B—being a member of the broader SNORD group—could share similar roles in contributing to aberrant RNA processing and possibly to the pathogenesis of AD. Such differential enrichment, if confirmed in future analyses, may provide a rationale for exploring SNORD15B as an additional non‐invasive biomarker for early AD diagnosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Moreover, the data from this investigation support the broader concept that changes in snoRNA profiles in biofluids can reflect underlying neurodegeneration. In light of SNORD15B’s canonical roles in guiding RNA modifications, further research into its expression dynamics and functional impact in neuronal cells and in plasma extracellular vesicles could reveal novel insights into AD pathology and aid in refining biomarker panels for the disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Nicholas F Fitz, Jiebiao Wang, M Ilyas Kamboh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Small nucleolar RNAs in plasma extracellular vesicles and their discriminatory power as diagnostic biomarkers of Alzheimer's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurobiol Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.nbd.2021.105481"}], "href": "https://doi.org/10.1016/j.nbd.2021.105481"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34411703"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34411703"}]}]}]}