{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSNORD17 is significantly upregulated in hepatocellular carcinoma (HCC), where it contributes to tumor progression by impairing the normal tumor suppressor functions of p53. In HCC tissues, elevated SNORD17 expression correlates with poor patient prognosis, particularly in tumors harboring wild-type p53, suggesting its potential as a prognostic marker for aggressive disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Dis primis duis mauris potenti non at sociosqu ultricies massa. Mechanistic studies have revealed that SNORD17 simultaneously binds to nucleophosmin 1 (NPM1) and MYB binding protein 1a (MYBBP1A) within the nucleolus, effectively anchoring these proteins and preventing their translocation into the nucleoplasm. This retention obstructs the NPM1/MDM2-mediated stabilization and the MYBBP1A/p300-mediated activation of p53, thereby inhibiting p53-dependent cell cycle arrest and apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Fusce class lectus fringilla commodo sit blandit pellentesque. Moreover, a positive feedback loop reinforces this oncogenic process: p300-mediated acetylation of p53 suppresses SNORD17 expression by binding to its promoter, perpetuating the inhibition of p53 signaling. Preclinical studies further demonstrated that administration of SNORD17 antisense oligonucleotides (ASOs) significantly reduced the growth of xenograft tumors in mice, highlighting the potential of SNORD17 as a therapeutic target in HCC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Junnan Liang, Ganxun Li, Jingyu Liao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Non-coding small nucleolar RNA SNORD17 promotes the progression of hepatocellular carcinoma through a positive feedback loop upon p53 inactivation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Differ (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41418-022-00929-w"}], "href": "https://doi.org/10.1038/s41418-022-00929-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35034103"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35034103"}]}]}]}