{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIt is important to note that none of the provided abstracts describe or discuss SNORD18A. Instead, the collection of studies focuses on the diverse roles of the neuronal cell adhesion molecule TAG‐1 (also known as CNTN2) and its interacting partners in the developing and mature nervous system."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThese abstracts collectively demonstrate that TAG‐1 is critical for a number of neurodevelopmental processes. For example, TAG‐1 mediates axonal guidance and fasciculation, regulates neuronal polarization and migration, and ensures the proper clustering of ion channels at juxtaparanodal regions of myelinated fibers."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "8"}]}, {"type": "t", "text": " Moreover, TAG‐1’s function extends to supporting synaptic organization and maintenance, as well as modulating signal transduction pathways that influence neurogenesis and overall brain histogenesis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, the studies highlight how TAG‐1 and its interacting proteins contribute not only to normal neurodevelopment but also to the pathogenesis of several neurological conditions. Alterations in TAG‐1 signaling and localization have been associated with aberrant neurogenesis, myelination defects, and even links to neurodevelopmental disorders such as autism and epilepsy."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "17"}]}, {"type": "t", "text": " Additional reports further illustrate that TAG‐1 is essential for the maintenance of neural circuits, affecting aspects like olfactory bulb formation and motor neuron migration, as well as offering novel in vivo tools to modulate its expression (e.g., via transgenic models)."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "18", "end_ref": "24"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "S Raisa Eng, Serguei Kozlov, Eric E Turner "}, {"type": "b", "children": [{"type": "t", "text": "Unaltered expression of Bcl-2 and TAG-1/axonin-1 precedes sensory apoptosis in Brn3a knockout mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuroreport (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/00001756-200302100-00002"}], "href": "https://doi.org/10.1097/00001756-200302100-00002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12598723"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12598723"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Maria Traka, Laurence Goutebroze, Natalia Denisenko, et al. 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