| HGNC Family | Non-coding RNAs |
| Name | small nucleolar RNA, C/D box 21 |
| Description | This gene encodes a small nucleolar RNA (snoRNA) that may be involved in biogenesis of the large (28S) ribosomal subunit. This gene is found within an intron of the RPL5 gene. [provided by RefSeq, Mar 2009] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSNORD21 is a member of the C/D box small nucleolar RNAs known primarily for guiding 2′-O-methylation of ribosomal RNA, yet its potential regulatory roles in development remain to be fully elucidated. In a study designed to uncover factors critical for tooth root morphogenesis, a novel experimental system was employed to identify molecular players contributing to root development, suggesting that nuanced RNA modifications may be among the mechanisms influencing tissue patterning and functionality."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Although SNORD21 was not directly characterized in this investigation, its established role in RNA modification raises the possibility that it could impact gene expression dynamics underlying root formation."}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn a separate investigation focusing on ATP-dependent chromatin-remodeling enzymes—specifically CHD3 and CHD4—and their roles in embryonic vascular, gonadal, and brain development, the authors explored how epigenetic modulation contributes to proper tissue integrity and survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " While explicit functional data on SNORD21 were not provided, the emerging interplay between chromatin-based regulation and RNA-mediated modifications implies that SNORD21 might indirectly influence developmental processes by fine-tuning the gene expression programs necessary for proper organogenesis."}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Y Date, Y Yokoyama, H Kondo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Restricted expression of chromatin remodeling associated factor Chd3 during tooth root development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Periodontal Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1600-0765.2011.01419.x"}], "href": "https://doi.org/10.1111/j.1600-0765.2011.01419.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21972924"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21972924"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jun Xie, Siqi Gao, Christopher Schafer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The chromatin-remodeling enzyme CHD3 plays a role in embryonic viability but is dispensable for early vascular development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0235799"}], "href": "https://doi.org/10.1371/journal.pone.0235799"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32658897"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32658897"}]}]}]}
|
| Synonyms | U21, RNU21 |
| NCBI Gene ID | 6083 |
| API | |
| Download Associations | |
| Predicted Functions |
 |
| Co-expressed Genes |
|
| Expression in Tissues and Cell Lines |
|
SNORD21 has 1,087 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 16 datasets.
Click the + buttons to view associations for SNORD21 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of SNORD21 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of SNORD21 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of SNORD21 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of SNORD21 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at SNORD21 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of SNORD21 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of SNORD21 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of SNORD21 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of SNORD21 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of SNORD21 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of SNORD21 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of SNORD21 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of SNORD21 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of SNORD21 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at SNORD21 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| WikiPathways Pathways 2014 | pathways involving SNORD21 protein from the Wikipathways Pathways 2014 dataset. | |
