{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe collection of abstracts predominantly focuses on the functions of N‐terminal acetyltransferases and their regulatory partners—including mNAT1, mARD1, ARD1 variants, and Naa10—which play critical roles in diverse cellular processes such as cell cycle regulation, neuronal differentiation, osteogenesis, hypoxia response, genomic imprinting, redox homeostasis, and energy metabolism. Notably, these studies delineate how acetylation events modulate protein stability, protein–protein interactions, and transcriptional control in processes ranging from embryogenesis and bone development to oxidative stress response and adipocyte thermogenesis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nDespite the extensive exploration of these protein acetylation pathways, none of the publications provide any experimental data, discussion, or indication regarding the biological role of SNORD22. In these reports, attention is exclusively given to protein regulators—such as ARD1 and Naa10—and their molecular targets, including transcription factors and key metabolic regulators (e.g., Runx2, HIF-1α, and Pgc1α), with no mention of SNORD22 or any small nucleolar RNAs."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, while some studies extend the examination of N-terminal acetylation to developmental and morphological outcomes in mouse models—elucidating compensatory mechanisms (e.g., the existence of Naa12 alongside Naa10) and the impact of altered acetylation on embryonic viability and differentiation—the specific function of SNORD22 remains unaddressed across these diverse contexts."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "12"}]}, {"type": "t", "text": " \nThus, while these abstracts collectively enrich our understanding of acetyltransferase-mediated regulation in mammalian systems, they do not provide any insights into the function or regulatory mechanisms associated with SNORD22.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Naoaki Sugiura, Suzanne M Adams, Roderick A Corriveau "}, {"type": "b", "children": [{"type": "t", "text": "An evolutionarily conserved N-terminal acetyltransferase complex associated with neuronal development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M301218200"}], "href": "https://doi.org/10.1074/jbc.M301218200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12888564"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12888564"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Se-Hee Kim, Jeong Ae Park, Jin Hyoung Kim, et al. 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