{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nOocyte‐specific linker histone H1foo has been extensively studied for its role in organizing chromatin and regulating gene expression during oogenesis and early embryogenesis. Multiple studies have demonstrated that H1foo is uniquely expressed in growing oocytes and persists into the early embryonic stages, where it modulates nucleosomal organization, chromatin decondensation, and epigenetic status. Its transcript undergoes alternative splicing, and the encoded protein localizes predominantly to heterochromatic regions, thereby impacting gene expression, pluripotency, and cell fate decisions. In addition, ectopic and knockdown experiments have linked H1foo to successful oocyte maturation, maintenance of the undifferentiated state in embryonic stem cells, and enhanced reprogramming efficiency in the formation of induced pluripotent stem cells. Collectively, these findings underline the critical contribution of H1foo to chromatin architecture and epigenetic regulation during early development."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn contrast, a study focused on plasma cell dyscrasia identified SNORD25—a small nucleolar RNA—as a potential biomarker in smoldering myeloma. In this work, overexpression of SNORD25 (along with SNORD27, SNORD30, and SNORD31) was correlated with a shorter time to progression from asymptomatic disease to symptomatic myeloma, highlighting its potential involvement in the molecular pathogenesis and prognosis of high‐risk smoldering myeloma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Mamoru Tanaka, Maki Kihara, Blazej Meczekalski, et al. "}, {"type": "b", "children": [{"type": "t", "text": "H1oo: a pre-embryonic H1 linker histone in search of a function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Endocrinol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0303-7207(03)00054-6"}], "href": "https://doi.org/10.1016/s0303-7207(03"}, {"type": "t", "text": "00054-6) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12770723"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12770723"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Mamoru Tanaka, Maki Kihara, Jon D Hennebold, et al. "}, {"type": "b", "children": [{"type": "t", "text": "H1FOO is coupled to the initiation of oocytic growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Reprod (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1095/biolreprod.104.032474"}], "href": "https://doi.org/10.1095/biolreprod.104.032474"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15371275"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15371275"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Masataka Furuya, Mamoru Tanaka, Takahide Teranishi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "H1foo is indispensable for meiotic maturation of the mouse oocyte."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Reprod Dev (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1262/jrd.19008"}], "href": "https://doi.org/10.1262/jrd.19008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17519519"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17519519"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Chiaki Maeda, Shun Sato, Naoko Hattori, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DNA hypomethylation circuit of the mouse oocyte-specific histone H1foo gene in female germ cell lineage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Reprod (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1095/biolreprod.107.066522"}], "href": "https://doi.org/10.1095/biolreprod.107.066522"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18184919"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18184919"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Kazunobu Tsunemoto, Masayuki Anzai, Toshiki Matsuoka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cis-acting elements (E-box and NBE) in the promoter region of three maternal genes (Histone H1oo, Nucleoplasmin 2, and Zygote Arrest 1) are required for oocyte-specific gene expression in the mouse."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Reprod Dev (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mrd.20863"}], "href": "https://doi.org/10.1002/mrd.20863"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18324673"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18324673"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Koji Hayakawa, Jun Ohgane, Satoshi Tanaka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oocyte-specific linker histone H1foo is an epigenomic modulator that decondenses chromatin and impairs pluripotency."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Epigenetics (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/epi.21492"}], "href": "https://doi.org/10.4161/epi.21492"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22868987"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22868987"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Akira Kunitomi, Shinsuke Yuasa, Fumihiro Sugiyama, et al. "}, {"type": "b", "children": [{"type": "t", "text": "H1foo Has a Pivotal Role in Qualifying Induced Pluripotent Stem Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cell Reports (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.stemcr.2016.04.015"}], "href": "https://doi.org/10.1016/j.stemcr.2016.04.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27237376"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27237376"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Satoshi Funaya, Masatoshi Ooga, Masataka G Suzuki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Linker histone H1FOO regulates the chromatin structure in mouse zygotes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1873-3468.13175"}], "href": "https://doi.org/10.1002/1873-3468.13175"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29963710"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29963710"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Koji Hayakawa, Satoshi Tanaka "}, {"type": "b", "children": [{"type": "t", "text": "Oocyte-specific linker histone H1foo interacts with Esrrb to induce chromatin decondensation at specific gene loci."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2021.05.033"}], "href": "https://doi.org/10.1016/j.bbrc.2021.05.033"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34023782"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34023782"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Fernando Sánchez-Sáez, Raquel Sainz-Urruela, Natalia Felipe-Medina, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Oocyte-Specific Linker Histone H1FOO Is Not Essential for Mouse Oogenesis and Fertility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cells (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cells11223706"}], "href": "https://doi.org/10.3390/cells11223706"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36429134"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36429134"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Lucía López-Corral, María Victoria Mateos, Luis A Corchete, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genomic analysis of high-risk smoldering multiple myeloma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Haematologica (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3324/haematol.2011.060780"}], "href": "https://doi.org/10.3324/haematol.2011.060780"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22331267"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22331267"}]}]}]}