SNORD35A Gene

HGNC Family Non-coding RNAs
Name small nucleolar RNA, C/D box 35A
Description Predicted to be involved in RNA processing. Predicted to act upstream of or within glucose metabolic process; insulin secretion; and reactive oxygen species metabolic process. Predicted to be located in nucleolus. [provided by Alliance of Genome Resources, Mar 2025]
Summary
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For example, ATIP1 was shown to associate with the angiotensin II type 2 receptor to inhibit receptor tyrosine kinase signaling, thereby reducing growth factor–induced ERK activation and DNA synthesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional work in the context of cancer and cardiovascular disease demonstrates that MTUS1 gene products, including ATIP3, modulate key cellular processes such as microtubule dynamics, cell motility, and proliferation. In breast cancer, reduced levels of ATIP3 correlate with increased metastasis and poor survival, while experimental models confirm that restoring ATIP3 expression stabilizes microtubules and impedes cancer cell migration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Likewise, ATIP1 overexpression in transgenic mice reduced neointimal formation and dampened inflammatory signaling in vascular remodeling, highlighting the protein’s protective role in the vasculature."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, studies using MTUS1 knockout mice and bone marrow transplantation models underscore the anti-proliferative and anti-inflammatory effects of ATIP/MTUS1 gene products, as evidenced by heart hypertrophy, lymphoid hyperplasia, and altered macrophage polarization in adipose tissue, all of which contribute to metabolic and inflammatory dysregulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Finally, early developmental studies hint at additional, yet-to-be elucidated roles for ATIP isoforms."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " In summary, while the function of SNORD35A was not addressed in these abstracts, the body of work emphasizes that ATIP/MTUS1 proteins operate as multi-faceted regulators that inhibit proliferative, migratory, and inflammatory pathways, thereby serving pivotal roles in tumor suppression, vascular protection, and metabolic homeostasis.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sandrine Nouet, Nathalie Amzallag, Jian-Mei Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M403880200"}], "href": "https://doi.org/10.1074/jbc.M403880200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15123706"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15123706"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Sylvie Rodrigues-Ferreira, Anne Di Tommaso, Ariane Dimitrov, et al. "}, {"type": "b", "children": [{"type": "t", "text": "8p22 MTUS1 gene product ATIP3 is a novel anti-mitotic protein underexpressed in invasive breast carcinoma of poor prognosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0007239"}], "href": "https://doi.org/10.1371/journal.pone.0007239"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19794912"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19794912"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Angie Molina, Lauriane Velot, Lydia Ghouinem, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ATIP3, a novel prognostic marker of breast cancer patient survival, limits cancer cell migration and slows metastatic progression by regulating microtubule dynamics."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-12-3565"}], "href": "https://doi.org/10.1158/0008-5472.CAN-12-3565"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23396587"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23396587"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Teppei Fujita, Masaki Mogi, Li-Juan Min, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Attenuation of cuff-induced neointimal formation by overexpression of angiotensin II type 2 receptor-interacting protein 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hypertension (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/HYPERTENSIONAHA.108.128140"}], "href": "https://doi.org/10.1161/HYPERTENSIONAHA.108.128140"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19221207"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19221207"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Masayoshi Kukida, Masaki Mogi, Kousei Ohshima, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Angiotensin II Type 2 Receptor Inhibits Vascular Intimal Proliferation With Activation of PPARγ."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hypertens (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/ajh/hpv168"}], "href": "https://doi.org/10.1093/ajh/hpv168"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26471325"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26471325"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Christina Zuern, Laszlo Krenacs, Stephanie Starke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Microtubule associated tumor suppressor 1 deficient mice develop spontaneous heart hypertrophy and SLE-like lymphoproliferative disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2011.1311"}], "href": "https://doi.org/10.3892/ijo.2011.1311"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22200760"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22200760"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Fei Jing, Masaki Mogi, Li-Juan Min, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effect of angiotensin II type 2 receptor-interacting protein on adipose tissue function via modulation of macrophage polarization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0060067"}], "href": "https://doi.org/10.1371/journal.pone.0060067"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23565185"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23565185"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Karin Bundschu, Kai Schuh "}, {"type": "b", "children": [{"type": "t", "text": "Cardiovascular ATIP (Angiotensin receptor type 2 interacting protein) expression in mouse development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Dyn (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/dvdy.24102"}], "href": "https://doi.org/10.1002/dvdy.24102"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24288149"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24288149"}]}]}]}
Synonyms RNU35, RNU35A, U35
NCBI Gene ID 26816
API
Download Associations
Predicted Functions View SNORD35A's ARCHS4 Predicted Functions.
Co-expressed Genes View SNORD35A's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View SNORD35A's ARCHS4 Predicted Functions.

Functional Associations

SNORD35A has 2,001 functional associations with biological entities spanning 5 categories (molecular profile, functional term, phrase or reference, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 21 datasets.

Click the + buttons to view associations for SNORD35A from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of SNORD35A gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
CellMarker Gene-Cell Type Associations cell types associated with SNORD35A gene from the CellMarker Gene-Cell Type Associations dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of SNORD35A gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of SNORD35A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of SNORD35A gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at SNORD35A gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of SNORD35A gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of SNORD35A gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells PubMedIDs of publications reporting gene signatures containing SNORD35A from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing SNORD35A from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of SNORD35A gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of SNORD35A gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of SNORD35A gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of SNORD35A gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of SNORD35A gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of SNORD35A gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles cell lines with high or low expression of SNORD35A gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of SNORD35A gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of SNORD35A gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at SNORD35A gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
WikiPathways Pathways 2014 pathways involving SNORD35A protein from the Wikipathways Pathways 2014 dataset.