| HGNC Family | Non-coding RNAs |
| Name | small nucleolar RNA, C/D box 36A |
| Description | Predicted to be involved in RNA processing. Predicted to be located in nucleolus. [provided by Alliance of Genome Resources, Mar 2025] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn renal injury models, particularly in unilateral ureteral obstruction, the tubular basement membrane protein TINag plays a key role in maintaining tubular integrity. Oxidative stress leads to a reduction in TINag levels through impaired C/EBP‐beta activity, which in turn facilitates epithelial-to-mesenchymal transition and contributes to fibrosis. Notably, experimental data indicate that when epithelial cells are grown on a TINag substratum, they retain their differentiated phenotype and display reduced fibronectin synthesis, suggesting that TINag helps preserve normal epithelial architecture during injury."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "In the context of hepatocellular carcinoma, emerging evidence suggests that TINag may also be relevant to tumor biology. Although its established function has been primarily in renal pathology, recent studies involving HCC patient samples aim to uncover the clinical and prognostic impact of TINag expression in liver cancer, underscoring its potential role as a biomarker or pathogenic mediator in malignancy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ping Xie, Lin Sun, Baibasawata Nayak, et al. "}, {"type": "b", "children": [{"type": "t", "text": "C/EBP-beta modulates transcription of tubulointerstitial nephritis antigen in obstructive uropathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Soc Nephrol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1681/ASN.2008091007"}], "href": "https://doi.org/10.1681/ASN.2008091007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19297554"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19297554"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Meng-Hui Zhang, Hu Niu, Zheng Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activation of PI3K/AKT is involved in TINAG-mediated promotion of proliferation, invasion and migration of hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biomark (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/CBM-181277"}], "href": "https://doi.org/10.3233/CBM-181277"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29991125"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29991125"}]}]}]}
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| Synonyms | RNU36A, U36A |
| NCBI Gene ID | 26815 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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SNORD36A has 1,098 functional associations with biological entities spanning 5 categories (molecular profile, functional term, phrase or reference, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 17 datasets.
Click the + buttons to view associations for SNORD36A from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of SNORD36A gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of SNORD36A gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of SNORD36A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at SNORD36A gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of SNORD36A gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of SNORD36A gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing SNORD36A from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of SNORD36A gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of SNORD36A gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of SNORD36A gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of SNORD36A gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of SNORD36A gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of SNORD36A gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of SNORD36A gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of SNORD36A gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at SNORD36A gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| WikiPathways Pathways 2014 | pathways involving SNORD36A protein from the Wikipathways Pathways 2014 dataset. | |
