{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSNORD42B is a small nucleolar RNA that belongs to the C/D box family, primarily known for its canonical role in the chemical modification and processing of ribosomal RNA. Notably, recent investigations have indicated that SNORD42B exhibits diagnostic potential in oncology; for instance, plasma levels of SNORD42B were identified as an effective biomarker for early‐stage non–small cell lung cancer, suggesting that aberrant expression of this snoRNA may reflect early molecular derangements in tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn contrast to the extensive focus on receptor protein tyrosine phosphatases (such as PTPRO and related isoforms) in many of the collected studies—where these phosphatases regulate diverse processes including axon guidance, synapse formation, immune modulation, apoptosis, and tumor suppression—the functional narrative of SNORD42B appears to be distinct. None of the other abstracts address SNORD42B directly; rather, the emerging data on circulating snoRNAs complements these broader investigations by highlighting an additional, non‐canonical class of regulatory nucleic acids that may serve as minimally invasive biomarkers for early cancer detection. This underscores the potential for SNORD42B not only to contribute to ribosomal RNA maturation but also to provide clinically actionable insights in disease contexts such as lung cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kangyu Wang, Xingguo Song, Shiwen Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Plasma SNORD42B and SNORD111 as potential biomarkers for early diagnosis of non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Lab Anal (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcla.24740"}], "href": "https://doi.org/10.1002/jcla.24740"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36284435"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36284435"}]}]}]}