{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe abstracts provided do not report any results related to SNORD4B. Instead, they focus on the characterization of two type II transmembrane serine proteases – mouse DESC1 and TMPRSS11E – and describe their functions in different tissue contexts. For instance, the first study identified a cell surface protease (DESC1) with a defined multidomain structure that is involved in proteolytic processing at epithelial surfaces, suggesting a role in the maintenance and regulation of epidermal, oral, and reproductive tissues."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThe second study detailed how TMPRSS11E is upregulated during inflammatory responses in lung tissue, with experimental evidence indicating that its proteolytic activity may trigger proinflammatory signaling via the activation of protease‐activated receptor-1. This process appears to contribute to the aggravation of lung injury in response to various inflammatory challenges."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAlthough SNORD4B—a small nucleolar RNA typically associated with the post-transcriptional modification of ribosomal RNA—is not mentioned or functionally characterized in either of these abstracts, the detailed analyses provided for DESC1 and TMPRSS11E underscore the importance of proteolytic regulation in epithelial integrity and inflammatory signaling. If SNORD4B were to be implicated in similar pathways, its precise role would require further dedicated investigation beyond the scope of these studies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "John P Hobson, Sarah Netzel-Arnett, Roman Szabo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mouse DESC1 is located within a cluster of seven DESC1-like genes and encodes a type II transmembrane serine protease that forms serpin inhibitory complexes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M403299200"}], "href": "https://doi.org/10.1074/jbc.M403299200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15328353"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15328353"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wei Zhang, Zhenfa Chen, Ting Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased Expression of TMPRSS11E Is Involved in LPS- or Poly(I:C)-mediated Inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Respir Cell Mol Biol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1165/rcmb.2022-0256OC"}], "href": "https://doi.org/10.1165/rcmb.2022-0256OC"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36413750"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36413750"}]}]}]}