SNORD60 Gene

HGNC Family Non-coding RNAs
Name small nucleolar RNA, C/D box 60
Description Predicted to be involved in RNA processing. Predicted to act upstream of or within intracellular cholesterol transport. Predicted to be located in nucleolus. [provided by Alliance of Genome Resources, Mar 2025]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSNORD60 is a small nucleolar RNA (snoRNA) of the C/D box class that has been recently implicated in the pathogenesis of endometrial carcinoma. In endometrial cancer tissues, SNORD60 is significantly upregulated compared to normal endometrial tissues. It forms a ribonucleoprotein complex by binding to the 2′-O-methyltransferase fibrillarin, thereby catalyzing the 2′-O-methylation (Nm) modification of specific messenger RNAs. One key target is the mRNA encoding PIK3CA, a central component of the PI3K/AKT/mTOR signaling pathway that drives cell proliferation and survival. This modification upregulates PIK3CA expression, ultimately enhancing the oncogenic signaling that promotes tumor growth and progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFunctionally, the SNORD60‐mediated modification of PIK3CA mRNA contributes to increased cellular proliferation, migration, and invasion observed in endometrial carcinoma. Moreover, experimental interventions have demonstrated that knocking down SNORD60 or disrupting its association with fibrillarin—and thereby impeding the aberrant methylation of PIK3CA mRNA—can reverse these carcinogenic effects. These findings suggest that SNORD60 is not only essential for modulating the PI3K/AKT/mTOR axis in endometrial cancer but also might serve as a promising diagnostic biomarker and therapeutic target in this disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wu Wu, Xi Chen, Xin Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SNORD60 promotes the tumorigenesis and progression of endometrial cancer through binding PIK3CA and regulating PI3K/AKT/mTOR signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Carcinog (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mc.23495"}], "href": "https://doi.org/10.1002/mc.23495"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36562475"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36562475"}]}]}]}
Synonyms RNU60, U60
NCBI Gene ID 26788
API
Download Associations
Predicted Functions View SNORD60's ARCHS4 Predicted Functions.
Co-expressed Genes View SNORD60's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View SNORD60's ARCHS4 Predicted Functions.

Functional Associations

SNORD60 has 1,657 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 17 datasets.

Click the + buttons to view associations for SNORD60 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of SNORD60 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of SNORD60 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of SNORD60 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of SNORD60 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at SNORD60 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of SNORD60 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of SNORD60 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing SNORD60 from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of SNORD60 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of SNORD60 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of SNORD60 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of SNORD60 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of SNORD60 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles cell lines with high or low expression of SNORD60 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of SNORD60 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of SNORD60 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at SNORD60 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.