{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn melanoma, reduced levels of a key non‐coding RNA equivalent in function to miR‑768‑3p, as reported in one study, were shown to drive tumor progression by unleashing the translation machinery. Specifically, activation of the MEK/ERK pathway downregulated miR‑768‑3p, which in turn led to an upregulation of eIF4E—the rate‐limiting factor in cap‑dependent translation—and a consequent increase in global protein synthesis that supports cell survival and proliferation. Although this study did not directly investigate SNORD71, the findings underscore how dysregulation of small non‑coding RNAs can perturb translational control processes, a concept that is relevant when considering the potential impact of other non‑coding RNAs such as SNORD71 on cellular homeostasis and malignancy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}, {"type": "p", "children": [{"type": "t", "text": "\nIn non‑small cell lung carcinoma (NSCLC), elevated levels of miR‑768‑3p were associated with disease progression. Inhibition of miR‑768‑3p using antagomirs in NSCLC models led to marked increases in cell apoptosis, as well as significant reductions in cell viability, migration, and invasion—accompanied by decreased matrix metalloproteinase activities. While the study specifically focused on miR‑768‑3p, its demonstration of how small non‑coding RNAs modulate critical cellular functions provides a conceptual framework that may be extended to other small RNAs such as SNORD71, potentially implicating them in similar regulatory and oncogenic pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of HBV‑related hepatocellular carcinoma (HCC), clinical analyses showed that low serum levels of miR‑768‑3p serve as both a diagnostic and prognostic biomarker. Patients with reduced miR‑768‑3p presented with more advanced tumor stages and poorer outcomes; in vitro, overexpression of miR‑768‑3p significantly inhibited HCC cell proliferation, migration, and invasion. Although SNORD71 was not directly addressed in this investigation, these data highlight the fundamental role of small non‑coding RNAs in regulating tumor biology. Such findings raise the possibility that SNORD71, typically involved in ribosomal RNA modification, might also influence cancer pathogenesis through analogous mechanisms."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}]}]}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "C C Jiang, A Croft, H-Y Tseng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Repression of microRNA-768-3p by MEK/ERK signalling contributes to enhanced mRNA translation in human melanoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2013.237"}], "href": "https://doi.org/10.1038/onc.2013.237"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23770856"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23770856"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zuozhou Xie, Weiqiang Chen, Yinghua Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-768-3p is involved in the proliferation, invasion and migration of non-small cell lung carcinomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2017.4133"}], "href": "https://doi.org/10.3892/ijo.2017.4133"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29048613"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29048613"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Chunyu Cao, Changjiang Wang "}, {"type": "b", "children": [{"type": "t", "text": "Clinical significance of serum miR-768-3p in HBV-related hepatocellular carcinoma and its potential mechanism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Exp Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10238-020-00646-z"}], "href": "https://doi.org/10.1007/s10238-020-00646-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32712720"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32712720"}]}]}]}