{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough the query requests a summary of the function of SNORD81, neither of the provided abstracts (PMID"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "and PMID"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "contains any mention or description of SNORD81. Instead, both studies focus on characterizing the functions of a protein known as Liar (Lyn‐interacting ankyrin repeat protein), which interacts with several tyrosine kinases.\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the first study (PMID"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", the authors demonstrate that Liar facilitates the nuclear export of Bruton’s tyrosine kinase (Btk) and Txk/Rlk in a Crm1‐dependent manner. The nuclear–cytoplasmic shuttling mediated by Liar is shown to be specific to the nonphosphorylated activation loop form of Btk and is contingent upon an intact SH3 domain. In the second study (PMID"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", Liar is identified as a critical modulator of erythropoietin (Epo)–induced signaling. Here, Liar interacts with Lyn and HS1, affecting downstream pathways (including Erk2, STAT5, Akt, and Lyn itself) and thereby influencing the differentiation of erythroid progenitors.\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn summary, while the provided abstracts offer important insights into Liar’s role in mediating nucleocytoplasmic transport of tyrosine kinases and regulating erythroid differentiation through modulation of intracellular signaling, they do not address the function of SNORD81. Therefore, any information regarding SNORD81 remains unaddressed in these publications.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Amy L Samuels, S Peter Klinken, Evan Ingley "}, {"type": "b", "children": [{"type": "t", "text": "Liar, a novel Lyn-binding nuclear/cytoplasmic shuttling protein that influences erythropoietin-induced differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2008-04-153452"}], "href": "https://doi.org/10.1182/blood-2008-04-153452"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19064729"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19064729"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Manuela O Gustafsson, Alamdar Hussain, Dara K Mohammad, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of nucleocytoplasmic shuttling of Bruton's tyrosine kinase (Btk) through a novel SH3-dependent interaction with ankyrin repeat domain 54 (ANKRD54)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.06620-11"}], "href": "https://doi.org/10.1128/MCB.06620-11"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22527282"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22527282"}]}]}]}