SNORD89 Gene

HGNC Family Non-coding RNAs
Name small nucleolar RNA, C/D box 89
Description Predicted to be involved in RNA processing. Predicted to be located in nucleolus. [provided by Alliance of Genome Resources, Mar 2025]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSNORD89, a member of the small nucleolar RNA family, has emerged as an important regulatory molecule in ovarian cancer—a disease where the maintenance of cancer stem cell (CSC) properties underlies tumor initiation, progression, and treatment resistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \nIn ovarian cancer, dysregulation of snoRNAs like SNORD89 is thought to contribute to the preservation of CSC traits by modulating pathways involved in self‐renewal and differentiation, thereby promoting aggressive tumor behavior and chemoresistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\nGiven these insights, SNORD89 represents a potential molecular target for novel therapeutic strategies aimed at disrupting the CSC-driven tumorigenic processes, which may ultimately improve clinical outcomes in patients with ovarian cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wenjing Zhu, Jumin Niu, Miao He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SNORD89 promotes stemness phenotype of ovarian cancer cells by regulating Notch1-c-Myc pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Transl Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12967-019-2005-1"}], "href": "https://doi.org/10.1186/s12967-019-2005-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31395064"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31395064"}]}]}]}
Synonyms HBII-289
NCBI Gene ID 692205
API
Download Associations
Predicted Functions View SNORD89's ARCHS4 Predicted Functions.
Co-expressed Genes View SNORD89's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View SNORD89's ARCHS4 Predicted Functions.

Functional Associations

SNORD89 has 1,216 functional associations with biological entities spanning 5 categories (molecular profile, disease, phenotype or trait, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 19 datasets.

Click the + buttons to view associations for SNORD89 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq tissue samples with high or low expression of SNORD89 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of SNORD89 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of SNORD89 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of SNORD89 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at SNORD89 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of SNORD89 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of SNORD89 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GEO Signatures of Differentially Expressed Genes for Diseases disease perturbations changing expression of SNORD89 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of SNORD89 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of SNORD89 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations transcription factor perturbations changing expression of SNORD89 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of SNORD89 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of SNORD89 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of SNORD89 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of SNORD89 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles cell lines with high or low expression of SNORD89 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of SNORD89 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at SNORD89 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
TCGA Signatures of Differentially Expressed Genes for Tumors tissue samples with high or low expression of SNORD89 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.