{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough none of the provided abstracts mention SNORD98, they offer a wealth of information on the cellular functions of hexokinase isoforms and their regulatory partners. Several studies demonstrate that mitochondrial‐bound hexokinases are central to cellular metabolism and survival. For example, one group showed that Akt‐dependent maintenance of hexokinase association with the outer mitochondrial membrane prevents cytochrome c release and subsequent apoptosis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " In a related study, synthetic peptides derived from mitochondrial channels disrupted hexokinase binding to mitochondria, thereby diminishing its anti‐apoptotic effects."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOther abstracts emphasize tissue‐specific roles of hexokinase isoforms. In the brain, for instance, hexokinase expression is highly enriched in neurons, implicating it as the principal mediator of glucose uptake needed for rapid neuronal activity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In addition, studies in sperm have identified a spermatogenic cell–specific form of hexokinase that is key to ATP production and motility."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Moreover, alterations in hexokinase localization and expression have been linked to metabolic imbalances in cardiac and inflammatory contexts."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional reports explore the genetic and pharmacologic modulation of hexokinase activity, revealing its broad impact on cell survival, cancer drug resistance, and metabolic homeostasis. For example, dietary influences and targeted genetic disruptions that alter hexokinase binding or expression have been shown to shift the balance of glucose metabolism, sometimes leading to inflammatory and degenerative outcomes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "16"}]}, {"type": "t", "text": " Furthermore, impaired hexokinase function has been implicated in resistance to tyrosine kinase inhibitors in hepatocellular carcinoma and in aberrant metabolic responses in Alzheimer’s disease."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "17", "end_ref": "19"}]}, {"type": "t", "text": " \n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn summary, while these abstracts richly detail the multifaceted roles of hexokinase in regulating metabolism, apoptosis, and cellular stress responses, they do not address any function for SNORD98. Consequently, no functional insights on SNORD98 can be drawn from this collection.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "L L Peters, P W Lane, S G Andersen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downeast anemia (dea), a new mouse model of severe nonspherocytic hemolytic anemia caused by hexokinase (HK(1)) deficiency."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood Cells Mol Dis (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1006/bcmd.2001.0454"}], "href": "https://doi.org/10.1006/bcmd.2001.0454"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11783948"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11783948"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ida W Smoak "}, {"type": "b", "children": [{"type": "t", "text": "Tolbutamide alters glucose transport and metabolism in the embryonic mouse heart."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Teratology (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/tera.1094"}], "href": "https://doi.org/10.1002/tera.1094"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11835228"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11835228"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Nathan Majewski, Veronique Nogueira, Prashanth Bhaskar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2004.11.014"}], "href": "https://doi.org/10.1016/j.molcel.2004.11.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15574336"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15574336"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Azamat Aslanukov, Reshma Bhowmick, Mallikarjuna Guruju, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.0020177"}], "href": "https://doi.org/10.1371/journal.pgen.0020177"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17069463"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17069463"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "N Goldin, L Arzoine, A Heyfets, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Methyl jasmonate binds to and detaches mitochondria-bound hexokinase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2008.108"}], "href": "https://doi.org/10.1038/onc.2008.108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18408762"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18408762"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Daniel Cifuentes, Carles Martínez-Pons, Mar García-Rocha, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hepatic glycogen synthesis in the absence of glucokinase: the case of embryonic liver."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M706334200"}], "href": "https://doi.org/10.1074/jbc.M706334200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18165236"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18165236"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Noriko Nakamura, Antonio Miranda-Vizuete, Kiyoshi Miki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cleavage of disulfide bonds in mouse spermatogenic cell-specific type 1 hexokinase isozyme is associated with increased hexokinase activity and initiation of sperm motility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Reprod (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1095/biolreprod.108.067561"}], "href": "https://doi.org/10.1095/biolreprod.108.067561"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18509164"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18509164"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Laetitia Arzoine, Noam Zilberberg, Ronit Ben-Romano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Voltage-dependent anion channel 1-based peptides interact with hexokinase to prevent its anti-apoptotic activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M803614200"}], "href": "https://doi.org/10.1074/jbc.M803614200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19049977"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19049977"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Janina Hantke, David Chandler, Rosalind King, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A mutation in an alternative untranslated exon of hexokinase 1 associated with hereditary motor and sensory neuropathy -- Russe (HMSNR)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Hum Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ejhg.2009.99"}], "href": "https://doi.org/10.1038/ejhg.2009.99"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19536174"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19536174"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Noriko Nakamura, Chisato Mori, Edward M Eddy "}, {"type": "b", "children": [{"type": "t", "text": "Molecular complex of three testis-specific isozymes associated with the mouse sperm fibrous sheath: hexokinase 1, phosphofructokinase M, and glutathione S-transferase mu class 5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Reprod (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1095/biolreprod.109.080580"}], "href": "https://doi.org/10.1095/biolreprod.109.080580"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19889946"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19889946"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Wei Wang, Qian Li, Jun Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hemokinin-1 activates the MAPK pathway and enhances B cell proliferation and antibody production."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.0901278"}], "href": "https://doi.org/10.4049/jimmunol.0901278"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20208012"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20208012"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Kirsten M Smeele, Leontien H ter Horst, Anneke Koeman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The effect of standard chow and reduced hexokinase II on growth, cardiac and skeletal muscle hexokinase and low-flow cardiac ischaemia-reperfusion injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Lab Anim (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1258/la.2011.010096"}], "href": "https://doi.org/10.1258/la.2011.010096"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21504994"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21504994"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Theodore A Craig, Pradeep L Ramachandran, H Robert Bergen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The regulation of apoptosis by the downstream regulatory element antagonist modulator/potassium channel interacting protein 3 (DREAM/KChIP3) through interactions with hexokinase I."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2013.03.016"}], "href": "https://doi.org/10.1016/j.bbrc.2013.03.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23524266"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23524266"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Iben Lundgaard, Baoman Li, Lulu Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms7807"}], "href": "https://doi.org/10.1038/ncomms7807"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25904018"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25904018"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Mingyu Kang, Sang Min Lee, Wanil Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Fubp1 supports the lactate-Akt-mTOR axis through the upregulation of Hk1 and Hk2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.03.005"}], "href": "https://doi.org/10.1016/j.bbrc.2019.03.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30871777"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30871777"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Shuangxue Han, Zhijun He, Cornelius Jacob, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effect of Increased IL-1β on Expression of HK in Alzheimer's Disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms22031306"}], "href": "https://doi.org/10.3390/ijms22031306"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33525649"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33525649"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Summer Sofer, Kevin Lamkiewicz, Shir Armoza Eilat, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A genome-wide CRISPR activation screen reveals Hexokinase 1 as a critical factor in promoting resistance to multi-kinase inhibitors in hepatocellular carcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.202101507RR"}], "href": "https://doi.org/10.1096/fj.202101507RR"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35147243"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35147243"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Adam De Jesus, Farnaz Keyhani-Nejad, Carolina M Pusec, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hexokinase 1 cellular localization regulates the metabolic fate of glucose."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2022.02.028"}], "href": "https://doi.org/10.1016/j.molcel.2022.02.028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35305311"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35305311"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Éva Borbély, Angéla Kecskés, József Kun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hemokinin-1 is a mediator of chronic restraint stress-induced pain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-023-46402-7"}], "href": "https://doi.org/10.1038/s41598-023-46402-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37973885"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37973885"}]}]}]}