SNRNP200 Gene

Name	small nuclear ribonucleoprotein 200kDa (U5)
Description	Pre-mRNA splicing is catalyzed by the spliceosome, a complex of specialized RNA and protein subunits that removes introns from a transcribed pre-mRNA segment. The spliceosome consists of small nuclear RNA proteins (snRNPs) U1, U2, U4, U5 and U6, together with approximately 80 conserved proteins. U5 snRNP contains nine specific proteins. This gene encodes one of the U5 snRNP-specific proteins. This protein belongs to the DEXH-box family of putative RNA helicases. It is a core component of U4/U6-U5 snRNPs and appears to catalyze an ATP-dependent unwinding of U4/U6 RNA duplices. Mutations in this gene cause autosomal-dominant retinitis pigmentosa. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined. [provided by RefSeq, Mar 2010]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSNRNP200 encodes the 200‐kDa helicase hBrr2, a pivotal component of the U4/U6–U5 small nuclear ribonucleoprotein complex that drives pre-messenger RNA splicing. hBrr2’s primary role is to catalyze the ATP‐dependent unwinding of the U4/U6 snRNA duplex—a critical step for spliceosome activation and later disassembly—and thus ensure the proper remodeling of RNA–protein complexes during spliceosome assembly. This essential function underpins accurate splice-site recognition and mRNA processing as demonstrated in multiple studies."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its core helicase activity, hBrr2 is subject to elaborate regulation through protein–protein interactions and intramolecular allosteric modulation. Regulatory factors such as Prp8 and FBP21 associate with hBrr2—engaging specific domains like its Sec63 region—and modulate its RNA-binding, ATPase, and unwinding activities in a reversible manner. Structural and computational studies have further revealed that hBrr2’s unique tandem helicase cassettes—the N-terminal cassette being catalytically active and the C-terminal serving as a regulatory pseudoenzyme—engage in long-range cross-talk that can fine-tune its enzymatic function during splicing."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMutations in SNRNP200 have been causally linked to autosomal dominant retinitis pigmentosa and other tissue‐specific dysfunctions, highlighting the broader biological relevance of hBrr2 beyond splicing. Disease-associated missense mutations compromise its RNA unwinding and spliceosome activation functions—resulting in aberrant splice-site selection, cryptic splicing, and defective mRNA maturation—thereby contributing to retinal degeneration and related pathologies. Intriguingly, emerging evidence also implicates hBrr2 in additional processes such as antiviral RNA sensing, modulation of apoptotic pathways in cancer cells, and even the regulation of mesenchymal stem cell proliferation and differentiation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "23"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chen Zhao, Deepti L Bellur, Shasha Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Autosomal-dominant retinitis pigmentosa caused by a mutation in SNRNP200, a gene required for unwinding of U4/U6 snRNAs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2009.09.020"}], "href": "https://doi.org/10.1016/j.ajhg.2009.09.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19878916"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19878916"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Paola Benaglio, Terri L McGee, Leonardo P Capelli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Next generation sequencing of pooled samples reveals new SNRNP200 mutations associated with retinitis pigmentosa."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.21485"}], "href": "https://doi.org/10.1002/humu.21485"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21618346"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21618346"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Karine F Santos, Sina Mozaffari Jovin, Gert Weber, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1208098109"}], "href": "https://doi.org/10.1073/pnas.1208098109"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23045696"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23045696"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ali Ehsani, Jessica V Alluin, John J Rossi "}, {"type": "b", "children": [{"type": "t", "text": "Cell cycle abnormalities associated with differential perturbations of the human U5 snRNP associated U5-200kD RNA helicase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0062125"}], "href": "https://doi.org/10.1371/journal.pone.0062125"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23637979"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23637979"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Zuzana Cvačková, Daniel Matějů, David Staněk "}, {"type": "b", "children": [{"type": "t", "text": "Retinitis pigmentosa mutations of SNRNP200 enhance cryptic splice-site recognition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.22481"}], "href": "https://doi.org/10.1002/humu.22481"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24302620"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24302620"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Sara J Bowne, Lori S Sullivan, Cheryl E Avery, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in the small nuclear riboprotein 200 kDa gene (SNRNP200) cause 1.6% of autosomal dominant retinitis pigmentosa."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Vis (2013)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24319334"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24319334"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Sina Mozaffari-Jovin, Traudy Wandersleben, Karine F Santos, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "The inactive C-terminal cassette of the dual-cassette RNA helicase BRR2 both stimulates and inhibits the activity of the N-terminal helicase unit."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA119.010964"}], "href": "https://doi.org/10.1074/jbc.RA119.010964"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31914407"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31914407"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Eva Absmeier, Karen Vester, Tahereh Ghane, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long-range allostery mediates cooperative adenine nucleotide binding by the Ski2-like RNA helicase Brr2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jbc.2021.100829"}], "href": "https://doi.org/10.1016/j.jbc.2021.100829"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34048711"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34048711"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Francesco Guidarelli Mattioli, Andrea Saltalamacchia, Alessandra Magistrato "}, {"type": "b", "children": [{"type": "t", "text": "Tracing Allostery in the Spliceosome Ski2-like RNA Helicase Brr2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Phys Chem Lett (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/acs.jpclett.3c03538"}], "href": "https://doi.org/10.1021/acs.jpclett.3c03538"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38517341"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38517341"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Robert Atkinson, Maria Georgiou, Chunbo Yang, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Mutations in ASCC3L1 on 2q11.2 are associated with autosomal dominant retinitis pigmentosa in a Chinese family."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Invest Ophthalmol Vis Sci (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1167/iovs.09-3725"}], "href": "https://doi.org/10.1167/iovs.09-3725"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19710410"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19710410"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Tiecheng Liu, Xin Jin, Xuemin Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel missense SNRNP200 mutation associated with autosomal dominant retinitis pigmentosa in a Chinese family."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0045464"}], "href": "https://doi.org/10.1371/journal.pone.0045464"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23029027"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23029027"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "X Zhang, T Y Y Lai, S W Y Chiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Contribution of SNRNP200 sequence variations to retinitis pigmentosa."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eye (Lond) (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/eye.2013.137"}], "href": "https://doi.org/10.1038/eye.2013.137"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23887765"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23887765"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Naoki Sato, Masao Maeda, Mai Sugiyama, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of SNW1 association with spliceosomal proteins promotes apoptosis in breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.366"}], "href": "https://doi.org/10.1002/cam4.366"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25450007"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25450007"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Nicolas Tremblay, Martin Baril, Laurent Chatel-Chaix, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Variability in clinical phenotypes of PRPF8-linked autosomal dominant retinitis pigmentosa correlates with differential PRPF8/SNRNP200 interactions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ophthalmic Genet (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/13816810.2017.1393825"}], "href": "https://doi.org/10.1080/13816810.2017.1393825"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29087248"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29087248"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Z Wu, M Zhong, M Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutation Analysis of Pre-mRNA Splicing Genes PRPF31, PRPF8, and SNRNP200 in Chinese Families with Autosomal Dominant Retinitis Pigmentosa."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Mol Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2174/1566524018666181024160452"}], "href": "https://doi.org/10.2174/1566524018666181024160452"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30360737"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30360737"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Christina Gerth-Kahlert, Samuel Koller, James V M Hanson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genotype-Phenotype Analysis of a Novel Recessive and a Recurrent Dominant SNRNP200 Variant Causing Retinitis Pigmentosa."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Invest Ophthalmol Vis Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1167/iovs.18-25643"}], "href": "https://doi.org/10.1167/iovs.18-25643"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31260034"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31260034"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Xiaomin Su, Haoqing Yang, Ruitang Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Depletion of SNRNP200 inhibits the osteo-/dentinogenic differentiation and cell proliferation potential of stem cells from the apical papilla."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Dev Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12861-020-00228-y"}], "href": "https://doi.org/10.1186/s12861-020-00228-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33203369"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33203369"}]}]}]}
Synonyms	U5-200KD, HELIC2, ASCC3L1, BRR2, RP33
Proteins	U520_HUMAN
NCBI Gene ID	23020
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SNRNP200 has 10,285 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 131 datasets.

Click the + buttons to view associations for SNRNP200 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SNRNP200 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by SNRNP200 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SNRNP200 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of SNRNP200 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of SNRNP200 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SNRNP200 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of SNRNP200 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SNRNP200 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of SNRNP200 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SNRNP200 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of SNRNP200 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SNRNP200 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SNRNP200 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with SNRNP200 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with SNRNP200 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SNRNP200 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SNRNP200 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SNRNP200 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with SNRNP200 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with SNRNP200 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing SNRNP200 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of SNRNP200 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SNRNP200 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing SNRNP200 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing SNRNP200 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing SNRNP200 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SNRNP200 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SNRNP200 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing SNRNP200 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of SNRNP200 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SNRNP200 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with SNRNP200 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with SNRNP200 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving SNRNP200 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving SNRNP200 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SNRNP200 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SNRNP200 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with SNRNP200 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with SNRNP200 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SNRNP200 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SNRNP200 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.