SNX16 Gene

HGNC Family	Sorting nexins (SNX)
Name	sorting nexin 16
Description	This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. The protein encoded by this gene associates with late endosome membranes as is involved in tubule formation, cholesterol transport, and transport of tetraspanin CD81. The encoded protein also inhibits cell migration and tumorigenesis. [provided by RefSeq, Jan 2017]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSNX16 is a sorting nexin defined by a central phosphoinositide‐binding (PX) domain and a C‐terminal coiled‐coil region, which together mediate its membrane association and homo‐oligomerization. This protein localizes to both early and late endosomal compartments and regulates the trafficking of internalized proteins such as epidermal growth factor and E‐cadherin, thereby influencing cargo segregation and recycling. In addition, candidate gene studies have examined sequence variants in SNX16 in the context of normal tension glaucoma, suggesting a potential role in ocular physiology."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n \nDisruption or altered expression of SNX16 has been implicated in disease pathogenesis. In colorectal cancer, SNX16 is markedly upregulated and promotes tumor cell growth by stabilizing eEF1A2 and activating downstream c‐Myc signaling. Moreover, in pre‐eclampsia, aberrant regulation of SNX16 via the BHLHE40/miR-196a-5p axis impairs trophoblast migration, thereby contributing to defective placentation. These findings, together with broader insights into SNX16’s roles in endocytosis, protein sorting, and signal transduction, underscore its multifaceted cellular functions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "6"}]}, {"type": "t", "text": "\n \nAdditionally, overexpression of SNX16 in hepatocellular carcinoma enhances cell invasion, proliferation, and epithelial–mesenchymal transition through modulation of the EGFR–AKT signaling cascade, highlighting its promise as a potential therapeutic target in cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Brendon J Hanson, Wanjin Hong "}, {"type": "b", "children": [{"type": "t", "text": "Evidence for a role of SNX16 in regulating traffic between the early and later endosomal compartments."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M300143200"}], "href": "https://doi.org/10.1074/jbc.M300143200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12813048"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12813048"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Christiane Wolf, Eugen Gramer, Bertram Müller-Myhsok, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Evaluation of nine candidate genes in patients with normal tension glaucoma: a case control study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Med Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2350-10-91"}], "href": "https://doi.org/10.1186/1471-2350-10-91"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19754948"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19754948"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jinxin Xu, Leilei Zhang, Yinghua Ye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SNX16 Regulates the Recycling of E-Cadherin through a Unique Mechanism of Coordinated Membrane and Cargo Binding."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Structure (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.str.2017.06.015"}], "href": "https://doi.org/10.1016/j.str.2017.06.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28712807"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28712807"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Zhiyong Shen, Yongsheng Li, Yuan Fang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SNX16 activates c-Myc signaling by inhibiting ubiquitin-mediated proteasomal degradation of eEF1A2 in colorectal cancer development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Oncol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1878-0261.12626"}], "href": "https://doi.org/10.1002/1878-0261.12626"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31876369"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31876369"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Chunmei Mi, Bin Ye, Zhou Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BHLHE40 plays a pathological role in pre-eclampsia through upregulating SNX16 by transcriptional inhibition of miR-196a-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Hum Reprod (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/molehr/gaaa037"}], "href": "https://doi.org/10.1093/molehr/gaaa037"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32579212"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32579212"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Fei-Yan Zeng, Yue-Fen Lou "}, {"type": "b", "children": [{"type": "t", "text": "[Sorting Nexin 16:Structure,Function,and Role in Diseases]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhongguo Yi Xue Ke Xue Yuan Xue Bao (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3881/j.issn.1000-503X.14468"}], "href": "https://doi.org/10.3881/j.issn.1000-503X.14468"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36373636"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36373636"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Lebin Yuan, Yanqiu Meng, Jiajia Xiang "}, {"type": "b", "children": [{"type": "t", "text": "SNX16 is required for hepatocellular carcinoma survival via modulating the EGFR-AKT signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-024-64015-6"}], "href": "https://doi.org/10.1038/s41598-024-64015-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38849490"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38849490"}]}]}]}
Proteins	SNX16_HUMAN
NCBI Gene ID	64089
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SNX16 has 5,142 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 111 datasets.

Click the + buttons to view associations for SNX16 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SNX16 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SNX16 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of SNX16 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SNX16 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of SNX16 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SNX16 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of SNX16 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SNX16 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SNX16 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of SNX16 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SNX16 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SNX16 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with SNX16 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with SNX16 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SNX16 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SNX16 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SNX16 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of SNX16 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SNX16 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing SNX16 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing SNX16 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing SNX16 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SNX16 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SNX16 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of SNX16 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SNX16 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with SNX16 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with SNX16 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with SNX16 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of SNX16 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by SNX16 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with SNX16 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SNX16 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SNX16 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with SNX16 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SNX16 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SNX16 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of SNX16 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing SNX16 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with SNX16 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with SNX16 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.