{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe body of work summarized herein provides a comprehensive view of the complex regulatory networks that govern skeletal muscle formation. These studies underscore the critical roles of myogenic transcription factors—most notably MyoD, Myf5, and Mrf4—as well as their downstream effectors and interacting partners (including Smad3, chromatin‐remodeling complexes, ubiquitin ligases, microRNAs, and various signaling proteins) in directing myoblast proliferation, commitment, differentiation, and even apoptosis. Collectively, these investigations reveal that precise orchestration of transcriptional activation, epigenetic modification, and signal transduction is essential for the timely progression of myogenesis and for robust muscle regeneration [."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "43"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nImportantly, despite the robust mechanistic detail provided by these studies on factors regulating myogenesis—from the initiation of myogenic gene expression and chromatin remodeling to the modulation of protein stability and signaling pathway integration—the provided abstracts do not report any direct investigation into the function of SNX19. In the context of these findings, the role of SNX19 (a sorting nexin family member typically implicated in membrane trafficking and intracellular signaling) remains unaddressed. Therefore, while the studies collectively deepen our understanding of myogenic regulation, they leave open the question of whether SNX19 might participate—directly or indirectly—in these complex processes. This gap highlights an enticing opportunity for future research to determine if SNX19 interacts with or modulates the signaling and transcriptional events that are central to muscle cell development and regeneration.\n(See citations above:"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "–."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "43"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chuan-ju Liu, Bo Ding, Hong Wang, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Hypoxia inhibits myogenic differentiation through accelerated MyoD degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M313931200"}], "href": "https://doi.org/10.1074/jbc.M313931200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14754880"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14754880"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Ramon C J Langen, Jos L J Van Der Velden, Annemie M W J Schols, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor necrosis factor-alpha inhibits myogenic differentiation through MyoD protein destabilization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.03-0251com"}], "href": "https://doi.org/10.1096/fj.03-0251com"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14769817"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14769817"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Swarnali Acharyya, Katherine J Ladner, Lori L Nelsen, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "A MyoD-generated feed-forward circuit temporally patterns gene expression during skeletal muscle differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.1234304"}], "href": "https://doi.org/10.1101/gad.1234304"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15466486"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15466486"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Lionel A Tintignac, Julie Lagirand, Sabrina Batonnet, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "MyoD targets chromatin remodeling complexes to the myogenin locus prior to forming a stable DNA-bound complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.25.10.3997-4009.2005"}], "href": "https://doi.org/10.1128/MCB.25.10.3997-4009.2005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15870273"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15870273"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Irena Rot-Nikcevic, Tyler Reddy, Kevin J Downing, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Myf5-/- :MyoD-/- amyogenic fetuses reveal the importance of early contraction and static loading by striated muscle in mouse skeletogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Genes Evol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00427-005-0024-9"}], "href": "https://doi.org/10.1007/s00427-005-0024-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16208536"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16208536"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Po Zhao, Giuseppina Caretti, Stephanie Mitchell, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Fgfr4 is required for effective muscle regeneration in vivo. 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"}, {"type": "b", "children": [{"type": "t", "text": "MyoD inhibits Fstl1 and Utrn expression by inducing transcription of miR-206."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200603039"}], "href": "https://doi.org/10.1083/jcb.200603039"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17030984"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17030984"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Atsushi Asakura, Hiroyuki Hirai, Boris Kablar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased survival of muscle stem cells lacking the MyoD gene after transplantation into regenerating skeletal muscle."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0708145104"}], "href": "https://doi.org/10.1073/pnas.0708145104"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17940048"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17940048"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Lance A Bare, Alanna C Morrison, Charles M Rowland, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Five common gene variants identify elevated genetic risk for coronary heart disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genet Med (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/gim.0b013e318156fb62"}], "href": "https://doi.org/10.1097/gim.0b013e318156fb62"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18073581"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18073581"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Maria Divina E Deato, Michael T Marr, Theo Sottero, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MyoD targets TAF3/TRF3 to activate myogenin transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2008.09.009"}], "href": "https://doi.org/10.1016/j.molcel.2008.09.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18851836"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18851836"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Ping Hu, Kenneth G Geles, Ji-Hye Paik, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Codependent activators direct myoblast-specific MyoD transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Cell (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.devcel.2008.08.018"}], "href": "https://doi.org/10.1016/j.devcel.2008.08.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18854138"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18854138"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Xi Chen, Kehui Wang, Jiangning Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "In vitro evidence suggests that miR-133a-mediated regulation of uncoupling protein 2 (UCP2) is an indispensable step in myogenic differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M807523200"}], "href": "https://doi.org/10.1074/jbc.M807523200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19073597"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19073597"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Alex Hennebry, Carole Berry, Victoria Siriett, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Myostatin regulates fiber-type composition of skeletal muscle by regulating MEF2 and MyoD gene expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Cell Physiol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpcell.00259.2007"}], "href": "https://doi.org/10.1152/ajpcell.00259.2007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19129464"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19129464"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Julie Lagirand-Cantaloube, Karen Cornille, Alfredo Csibi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of atrogin-1/MAFbx mediated MyoD proteolysis prevents skeletal muscle atrophy in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0004973"}], "href": "https://doi.org/10.1371/journal.pone.0004973"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19319192"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19319192"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Onur Kanisicak, Julio J Mendez, Shoko Yamamoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Progenitors of skeletal muscle satellite cells express the muscle determination gene, MyoD."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ydbio.2009.05.554"}], "href": "https://doi.org/10.1016/j.ydbio.2009.05.554"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19464281"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19464281"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Ramon Amat, Anna Planavila, Shen Liang Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SIRT1 controls the transcription of the peroxisome proliferator-activated receptor-gamma Co-activator-1alpha (PGC-1alpha) gene in skeletal muscle through the PGC-1alpha autoregulatory loop and interaction with MyoD."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.022749"}], "href": "https://doi.org/10.1074/jbc.M109.022749"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19553684"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19553684"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Yi Cao, Zizhen Yao, Deepayan Sarkar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide MyoD binding in skeletal muscle cells: a potential for broad cellular reprogramming."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Cell (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.devcel.2010.02.014"}], "href": "https://doi.org/10.1016/j.devcel.2010.02.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20412780"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20412780"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Hana Jeong, Sujung Bae, Su Yeon An, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TAZ as a novel enhancer of MyoD-mediated myogenic differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.09-151324"}], "href": "https://doi.org/10.1096/fj.09-151324"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20466877"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20466877"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Jessica L Andrews, Xiping Zhang, John J McCarthy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CLOCK and BMAL1 regulate MyoD and are necessary for maintenance of skeletal muscle phenotype and function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1014523107"}], "href": "https://doi.org/10.1073/pnas.1014523107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20956306"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20956306"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Hiroyuki Hirai, Mayank Verma, Shuichi Watanabe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MyoD regulates apoptosis of myoblasts through microRNA-mediated down-regulation of Pax3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201006025"}], "href": "https://doi.org/10.1083/jcb.201006025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20956382"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20956382"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Jinhong Zhu, Yong Li, Aiping Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Follistatin improves skeletal muscle healing after injury and disease through an interaction with muscle regeneration, angiogenesis, and fibrosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajpath.2011.04.008"}], "href": "https://doi.org/10.1016/j.ajpath.2011.04.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21689628"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21689628"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Sonia V Forcales, Sonia Albini, Lorenzo Giordani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Signal-dependent incorporation of MyoD-BAF60c into Brg1-based SWI/SNF chromatin-remodelling complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/emboj.2011.391"}], "href": "https://doi.org/10.1038/emboj.2011.391"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22068056"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22068056"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Belinda Mei Tze Ling, Narendra Bharathy, Teng-Kai Chung, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lysine methyltransferase G9a methylates the transcription factor MyoD and regulates skeletal muscle differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1111628109"}], "href": "https://doi.org/10.1073/pnas.1111628109"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22215600"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22215600"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Vahab D Soleimani, Hang Yin, Arezu Jahani-Asl, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Snail regulates MyoD binding-site occupancy to direct enhancer switching and differentiation-specific transcription in myogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2012.05.046"}], "href": "https://doi.org/10.1016/j.molcel.2012.05.046"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22771117"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22771117"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Dominique Bröhl, Elena Vasyutina, Maciej T Czajkowski, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Colonization of the satellite cell niche by skeletal muscle progenitor cells depends on Notch signals."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Cell (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.devcel.2012.07.014"}], "href": "https://doi.org/10.1016/j.devcel.2012.07.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22940113"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22940113"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Roy Blum, Vasupradha Vethantham, Christopher Bowman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide identification of enhancers in skeletal muscle: the role of MyoD1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.200113.112"}], "href": "https://doi.org/10.1101/gad.200113.112"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23249738"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23249738"}]}, {"type": "r", "ref": 39, "children": [{"type": "t", "text": "Hiroyuki Hirai, Nobuko Katoku-Kikyo, Susan A Keirstead, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Accelerated direct reprogramming of fibroblasts into cardiomyocyte-like cells with the MyoD transactivation domain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cardiovasc Res (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/cvr/cvt167"}], "href": "https://doi.org/10.1093/cvr/cvt167"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23794713"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23794713"}]}, {"type": "r", "ref": 40, "children": [{"type": "t", "text": "Adam C Mueller, Magdalena A Cichewicz, Bijan K Dey, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MUNC, a long noncoding RNA that facilitates the function of MyoD in skeletal myogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01079-14"}], "href": "https://doi.org/10.1128/MCB.01079-14"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25403490"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25403490"}]}, {"type": "r", "ref": 41, "children": [{"type": "t", "text": "Melissa L Conerly, Zizhen Yao, Jun Wen Zhong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distinct Activities of Myf5 and MyoD Indicate Separate Roles in Skeletal Muscle Lineage Specification and Differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Cell (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.devcel.2016.01.021"}], "href": "https://doi.org/10.1016/j.devcel.2016.01.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26906734"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26906734"}]}, {"type": "r", "ref": 42, "children": [{"type": "t", "text": "Jonathan Shintaku, Jennifer M Peterson, Erin E Talbert, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MyoD Regulates Skeletal Muscle Oxidative Metabolism Cooperatively with Alternative NF-κB."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2016.09.010"}], "href": "https://doi.org/10.1016/j.celrep.2016.09.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27705798"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27705798"}]}, {"type": "r", "ref": 43, "children": [{"type": "t", "text": "Xiaohua Yu, Yong Zhang, Tingting Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA Linc-RAM enhances myogenic differentiation by interacting with MyoD."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms14016"}], "href": "https://doi.org/10.1038/ncomms14016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28091529"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28091529"}]}]}]}